Regulation of and challenges in targeting NAD+ metabolism
Nicotinamide adenine dinucleotide, in its oxidized (NAD+) and reduced (NADH) forms, is a
reduction–oxidation (redox) co-factor and substrate for signalling enzymes that have …
reduction–oxidation (redox) co-factor and substrate for signalling enzymes that have …
[HTML][HTML] Preclinical and clinical evidence of NAD+ precursors in health, disease, and ageing
OK Reiten, MA Wilvang, SJ Mitchell, Z Hu… - Mechanisms of Ageing …, 2021 - Elsevier
NAD+ is a fundamental molecule in human life and health as it participates in energy
metabolism, cell signalling, mitochondrial homeostasis, and in dictating cell survival or …
metabolism, cell signalling, mitochondrial homeostasis, and in dictating cell survival or …
Dihydronicotinamide riboside is a potent NAD+ concentration enhancer in vitro and in vivo
Interest in pharmacological agents capable of increasing cellular NAD+ concentrations has
stimulated investigations of nicotinamide riboside (NR) and nicotinamide mononucleotide …
stimulated investigations of nicotinamide riboside (NR) and nicotinamide mononucleotide …
NRH salvage and conversion to NAD+ requires NRH kinase activity by adenosine kinase
Dihydronicotinamide riboside (NRH) has been suggested to act as a precursor for the
synthesis of NAD+, but the biochemical pathway converting it has been unknown. Here, we …
synthesis of NAD+, but the biochemical pathway converting it has been unknown. Here, we …
NQO1: A target for the treatment of cancer and neurological diseases, and a model to understand loss of function disease mechanisms
SK Beaver, N Mesa-Torres, AL Pey… - Biochimica et Biophysica …, 2019 - Elsevier
Abstract NAD (P) H quinone oxidoreductase 1 (NQO1) is a multi-functional protein that
catalyses the reduction of quinones (and other molecules), thus playing roles in xenobiotic …
catalyses the reduction of quinones (and other molecules), thus playing roles in xenobiotic …
NAD (P) H quinone oxidoreductase (NQO1): an enzyme which needs just enough mobility, in just the right places
Abstract NAD (P) H quinone oxidoreductase 1 (NQO1) catalyses the two electron reduction
of quinones and a wide range of other organic compounds. Its physiological role is believed …
of quinones and a wide range of other organic compounds. Its physiological role is believed …
Cobalt-Catalyzed Selective Dearomatization of Pyridines to N–H 1,4-Dihydropyridines
Catalytic reduction of pyridines to N–H 1, 4-dihydropyridines is exceptionally challenging
because they are essential intermediates to form tetrahydropyridines. Using a facile …
because they are essential intermediates to form tetrahydropyridines. Using a facile …
Azoreductases in drug metabolism
A Ryan - British Journal of Pharmacology, 2017 - Wiley Online Library
Azoreductases are flavoenzymes that have been characterized in a range of prokaryotes
and eukaryotes. Bacterial azoreductases are associated with the activation of two classes of …
and eukaryotes. Bacterial azoreductases are associated with the activation of two classes of …
Dihydronicotinamide riboside promotes cell-specific cytotoxicity by tipping the balance between metabolic regulation and oxidative stress
Nicotinamide adenine dinucleotide (NAD+), the essential cofactor derived from vitamin B3,
is both a coenzyme in redox enzymatic processes and substrate in non-redox events; …
is both a coenzyme in redox enzymatic processes and substrate in non-redox events; …
Structure and biocatalytic scope of thermophilic flavin-dependent halogenase and flavin reductase enzymes
BRK Menon, J Latham, MS Dunstan… - Organic & …, 2016 - pubs.rsc.org
Flavin-dependent halogenase (Fl-Hal) enzymes have been shown to halogenate a range of
synthetic as well as natural aromatic compounds. The exquisite regioselectively of Fl-Hal …
synthetic as well as natural aromatic compounds. The exquisite regioselectively of Fl-Hal …