Programmable gene-editing tools have transformed the life sciences and have shown
potential for the treatment of genetic disease. Among the CRISPR–Cas technologies that …

Prime editing (PE) is a precision gene editing technology that enables the programmable
installation of substitutions, insertions and deletions in cells and animals without requiring …

Prime editing is a versatile genome-editing technology, but it suffers from low editing
efficiency. In the present study, we introduce optimized prime editors with substantially …

Prime editing (PE) is a precise genome manipulation technology based on the “search and
replace” approach of the CRISPR-Cas9 system, while it does not require the exogenous …

Gene therapy holds tremendous potential in the treatment of inherited diseases. Unlike
traditional medicines, which only treat the symptoms, gene therapy has the potential to cure …

Genome editing continues to revolutionize biological research. Due to its simplicity and
flexibility, CRISPR/Cas-based editing has become the preferred technology in most systems …

Prime editing is an advanced gene editing platform with potential to correct almost any
disease-causing mutation. As genome editors have evolved, their size and complexity have …

Prime editing (PE), as a “search-and-replace” genome editing technology, has shown the
attractive potential of versatile genome editing ability, which is, in principle, currently …

The progress of genetic engineering in the 1970s brought about a paradigm shift in genome
editing technology. The clustered regularly interspaced short palindromic repeats/CRISPR …

We report the first correction from prime editing a mutation in the RYR1 gene, paving the
way to gene therapies for RYR1-related myopathies. The RYR1 gene codes for a calcium …