Persisters refer to genetically drug susceptible quiescent (non-growing or slow growing)
bacteria that survive in stress environments such as antibiotic exposure, acidic and …

Genomes of all living organisms are constantly threatened by endogenous and exogenous
agents that challenge the chemical integrity of DNA. Most bacteria have evolved a …

In a previous communication, we reported a new method of synthesis of stable metallic
copper nanoparticles (Cu-NPs), which had high potency for bacterial cell filamentation and …

DNA is one of the prime molecules, and its stability is of utmost importance for proper
functioning and existence of all living systems. Genotoxic chemicals and radiations exert …

Persisters are dormant variants of regular cells that form stochastically in microbial
populations and are highly tolerant to antibiotics. High persister (hip) mutants of …

The antibiotic ciprofloxacin is used extensively to treat a wide range of infections caused by
the opportunistic pathogen Pseudomonas aeruginosa. Due to its extensive use, the …

The presence of an abnormal amount of single-stranded DNA in the bacterial cell constitutes
a genotoxic alarm signal that induces the SOS response, a broad regulatory network found …

Homologous recombination (HR) is required for accurate chromosome segregation during
the first meiotic division and constitutes a key repair and tolerance pathway for complex DNA …

Transcription-coupled DNA repair (TCR) is presumed to be a minor sub-pathway of
nucleotide excision repair (NER) in bacteria. Global genomic repair is thought to perform the …

Almost all bacteria and many archaea contain genes whose expression inhibits cell growth
and may lead to cell death when overproduced, reminiscent of apoptotic genes in higher …