Ras homology (RHO) GTPases are signalling proteins that have crucial roles in triggering
multiple immune functions. Through their interactions with a broad range of effectors and …

Dedicator of cytokinesis (DOCK) proteins constitute a family of evolutionarily conserved
guanine nucleotide exchange factors (GEFs) for the Rho family of GTPases. Although DOCK …

Infections with any of the nine human herpes viruses (HHV) can be asymptomatic or life-
threatening. The study of patients with severe diseases caused by HHVs, in the absence of …

An increasing number of primary immunodeficiencies (PIDs) have been identified over the
last decade, which are caused by deleterious mutations in genes encoding for proteins …

Background Acute rejection (AR) in kidney transplantation is an established risk factor that
reduces the survival rate of allografts. Despite standard immunosuppression, molecules with …

Dedicator of cytokinesis 2 (DOCK2) can activate the downstream small G protein Rac and
regulate cytoskeletal reorganization. DOCK2 is essential for critical physiological processes …

Highlights•Human inborn errors of innate immunity can present as increased susceptibility to
infection with a narrow range of pathogens.•Non-hematopoietic tissue resident cells play a …

The dedicator of cytokinesis 2 (DOCK2) protein, an atypical guanine nucleotide exchange
factor (GEFs), is a member of the DOCKA protein subfamily. DOCK2 protein deficiency is …

During mucosal injury, intestinal immune cells play a crucial role in eliminating invading
bacteria. However, as the excessive accumulation of immune cells promotes inflammation …

Rac GTPases are required for neutrophil adhesion and migration, and for the neutrophil
effector responses that kill pathogens. These Rac-dependent functions are impaired when …