A review on human fecal metabolomics: Methods, applications and the human fecal metabolome database
Metabolomic analysis of human biospecimens had progressed quickly over the past
decade. Technological and methodological advances have led to the comprehensive …
decade. Technological and methodological advances have led to the comprehensive …
Interrogation of the mammalian gut–brain axis using LC–MS/MS-based targeted metabolomics with in vitro bacterial and organoid cultures and in vivo gnotobiotic …
TD Horvath, SJ Haidacher, MA Engevik, B Luck… - Nature …, 2023 - nature.com
Interest in the communication between the gastrointestinal tract and central nervous system,
known as the gut–brain axis, has prompted the development of quantitative analytical …
known as the gut–brain axis, has prompted the development of quantitative analytical …
[HTML][HTML] Human-derived Bifidobacterium dentium modulates the mammalian serotonergic system and gut–brain axis
MA Engevik, B Luck, C Visuthranukul… - Cellular and molecular …, 2021 - Elsevier
Background & Aims The human gut microbiota can regulate production of serotonin (5-
hydroxytryptamine [5-HT]) from enterochromaffin cells. However, the mechanisms …
hydroxytryptamine [5-HT]) from enterochromaffin cells. However, the mechanisms …
[HTML][HTML] Propionic acid shapes the multiple sclerosis disease course by an immunomodulatory mechanism
A Duscha, B Gisevius, S Hirschberg, N Yissachar… - Cell, 2020 - cell.com
Short-chain fatty acids are processed from indigestible dietary fibers by gut bacteria and
have immunomodulatory properties. Here, we investigate propionic acid (PA) in multiple …
have immunomodulatory properties. Here, we investigate propionic acid (PA) in multiple …
A prebiotic diet modulates microglial states and motor deficits in α-synuclein overexpressing mice
R Abdel-Haq, JCM Schlachetzki, JC Boktor… - Elife, 2022 - elifesciences.org
Parkinson's disease (PD) is a movement disorder characterized by neuroinflammation, α-
synuclein pathology, and neurodegeneration. Most cases of PD are non-hereditary …
synuclein pathology, and neurodegeneration. Most cases of PD are non-hereditary …
Advances and perspectives in chemical isotope labeling-based mass spectrometry methods for metabolome and exposome analysis
S Gao, X Zhou, M Yue, S Zhu, Q Liu, XE Zhao - TrAC Trends in Analytical …, 2023 - Elsevier
Metabolomics and exposomics are important in the studies of human health and diseases.
Chemical isotope labeling (CIL) combined with mass spectrometry (MS) can not only …
Chemical isotope labeling (CIL) combined with mass spectrometry (MS) can not only …
A compromised developmental trajectory of the infant gut microbiome and metabolome in atopic eczema
LDH Ta, JCY Chan, GC Yap, RW Purbojati… - Gut …, 2020 - Taylor & Francis
Evidence is accumulating that the establishment of the gut microbiome in early life
influences the development of atopic eczema. In this longitudinal study, we used integrated …
influences the development of atopic eczema. In this longitudinal study, we used integrated …
Experimental colonization with Blastocystis ST4 is associated with protective immune responses and modulation of gut microbiome in a DSS-induced colitis mouse …
Background Blastocystis is a common gut protistan parasite in humans and animals
worldwide, but its interrelationship with the host gut microbiota and mucosal immune …
worldwide, but its interrelationship with the host gut microbiota and mucosal immune …
[HTML][HTML] Colonization with two different Blastocystis subtypes in DSS-induced colitis mice is associated with strikingly different microbiome and pathological features
L Deng, L Wojciech, CW Png, DYQ Kioh, Y Gu… - Theranostics, 2023 - ncbi.nlm.nih.gov
Rationale: The gut microbiota plays a significant role in the pathogenesis of inflammatory
bowel disease (IBD). However, the role of Blastocystis infection and Blastocystis-altered gut …
bowel disease (IBD). However, the role of Blastocystis infection and Blastocystis-altered gut …
Calorie restriction improves metabolic state independently of gut microbiome composition: a randomized dietary intervention trial
Background The gut microbiota has been suggested to play a significant role in the
development of overweight and obesity. However, the effects of calorie restriction on gut …
development of overweight and obesity. However, the effects of calorie restriction on gut …