Ubiquitination has emerged as a crucial mechanism that regulates signal transduction in
diverse biological processes, including different aspects of immune functions. Ubiquitination …

The ability of naive T cells to clonally expand and acquire effector functions depends on the
strength of signals received by the T-cell receptor (TCR) and by an array of co-stimulatory …

Cancer immunotherapy has made great strides in the recent decade, especially in the area
of immune checkpoint blockade. The outstanding efficacy, prolonged durability of effect, and …

The tetraspanin web represents a new concept of molecular interactions in the immune
system. Whereas most surface immune-modulating molecules involve receptor–ligand …

CD28 costimulation regulates a wide range of cellular processes, from proliferation and
survival to promoting the differentiation of specialized T-cell subsets. Since first being …

T cell activation by antigen-presenting cells (APC) is regulated by positive and negative
costimulatory molecules in the B7 family. Here we describe a novel addition in this family …

T cell activation is regulated by the innate immune system through positive and negative
costimulatory molecules. B7-H3 is a novel B7-like molecule with a putative receptor on …

Ubiquitination plays a central role in the regulation of various biological functions including
immune responses. Ubiquitination is induced by a cascade of enzymatic reactions by E1 …

Notch1 specifically upregulates expression of the cytokine interferon‐γ in peripheral T cells
through activation of NF‐κB. However, how Notch mediates NF‐κB activation remains …

The glucocorticoid-induced TNF receptor (GITR), which is a member of the TNF receptor
family, is expressed preferentially at high levels on CD25+ CD4+ regulatory T cells and …