The term proteostasis reflects the fine-tuned balance of cellular protein levels, mediated
through a vast network of biochemical pathways. This requires the regulated control of …

Control of proper protein synthesis, function, and turnover is essential for the health of all
cells. In neurons these demands take on the additional importance of supporting and …

Significance: Impairment of the ubiquitin-proteasome system (UPS) has been implicated in
the pathogenesis of a wide variety of neurodegenerative disorders, including Alzheimer's …

Amyotrophic lateral sclerosis (ALS) is a neuronal degenerative condition identified via a
build-up of mutant aberrantly folded proteins. The native folding of polypeptides is mediated …

Cells regularly synthesize new proteins to replace old or damaged proteins. Deposition of
various aberrant proteins in specific brain regions leads to neurodegeneration and aging …

Background Dominant mutations in superoxide dismutase 1 (SOD1) cause degeneration of
motor neurons in a subset of inherited amyotrophic lateral sclerosis (ALS). The pathogenetic …

Angelman syndrome (AS) is a debilitating neurodevelopmental disorder that is
characterized by motor dysfunction, intellectual disability, speech impairment, seizures and …

Azadiradione is a small bioactive limonoid found in the seed of Azadirachta Indica, an Indian
medicinal plant commonly known as Neem. Recently, it has been shown to ameliorate the …

The abnormal accumulation of neurotoxic proteins is the typical hallmark of various age-
related neurodegenerative disorders (NDDs), including Alzheimer's disease, Parkinson's …

Human embryonic stem cells (hESCs) exhibit high levels of proteasome activity, an intrinsic
characteristic required for their self-renewal, pluripotency and differentiation. However, the …