Over two metres of DNA is packaged into each nucleus in the human body in a manner that
still allows for gene regulation. This remarkable feat is accomplished by the wrapping of …

The explosive growth of data in volume, velocity and diversity that are produced by medical
applications has contributed to abundance of big data. Current solutions for efficient data …

Predominantly occurring on cytosine, DNA methylation is a process by which cells can
modify their DNAs to change the expression of gene products. It plays very important roles in …

DNA methylation plays a crucial role in the regulation of gene expression and chromatin
organization within normal eukaryotic cells. In cancer, however, global patterns of DNA …

Background Recent assays for individual-specific genome-wide DNA methylation profiles
have enabled epigenome-wide association studies to identify specific CpG sites associated …

The hypo-or hyper-methylation of the human genome is one of the epigenetic features of
leukemia. However, experimental approaches have only determined the methylation state of …

DNA methylation in repetitive elements (RE) suppresses their mobility and maintains
genomic stability, and decreases in it are frequently observed in tumor and/or surrogate …

CpG islands were originally identified by epigenetic and functional properties, namely,
absence of DNA methylation and frequent promoter association. However, this concept was …

In this review, advances in the understanding of epigenetic reprogramming from fertilization
to the development of primordial germline cells in a mouse and human embryo are …

Epigenetic research aims to understand heritable gene regulation that is not directly
encoded in the DNA sequence. Epigenetic mechanisms such as DNA methylation and …