Disruptions in spatiotemporal gene expression can result in atypical brain function.
Specifically, autism spectrum disorder (ASD) is characterized by abnormalities in pre‐mRNA …

Over two dozen spliceosome proteins are involved in human diseases, also referred to as
spliceosomopathies. WW domain-binding protein 4 (WBP4) is part of the early spliceosomal …

Pre-mRNA splicing by the spliceosome requires the biogenesis and recycling of its small
nuclear ribonucleoprotein (snRNP) complexes, which are consumed in each round of …

The 20S U5 small nuclear ribonucleoprotein particle (snRNP) is a 17-subunit RNA–protein
complex and a precursor of the U4/U6. U5 tri-snRNP, the major building block of the …

The relationship between transcription and protein expression is complex. We identified
polysome-associated RNA transcripts in the somata and central terminals of mouse sensory …

Activating signal co-integrator 1 complex (ASCC) subunit 3 (ASCC3) supports diverse
genome maintenance and gene expression processes, and contains tandem Ski2-like …

ABSTRACT SART3 is a multifunctional protein that acts in several steps of gene expression,
including assembly and recycling of the spliceosomal U4/U6 small nuclear …

The question whether interference with the ubiquitous splicing machinery can lead to cell-
type specific perturbation of cellular function is addressed here by T cell specific ablation of …

Illuminating the role of chaperones in spliceosome biogenesis and recycling | Nature Structural
& Molecular Biology Skip to main content Thank you for visiting nature.com. You are using a …

Messenger RNAs (mRNAs) interact with RNA-binding proteins (RBPs) in diverse
ribonucleoprotein complexes (RNPs) during distinct life-cycle stages for their processing …