A main function of bacterial metabolism is to supply biomass building blocks and energy for
growth. This seems to imply that metabolism is idle in non-growing bacteria. But how …

Organic acids are an important class of compounds that can be produced by microbial
conversion of renewable feedstocks and have huge demands and broad applications in …

Transcriptomic data is accumulating rapidly; thus, scalable methods for extracting
knowledge from this data are critical. Here, we assembled a top-down expression and …

Response to acid stress is critical for Escherichia coli to successfully complete its life-cycle
by passing through the stomach to colonize the digestive tract. To develop a fundamental …

CsrA is an RNA-binding protein that regulates processes critical for growth and survival,
including central carbon metabolism, motility, biofilm formation, stress responses, and …

Introduction Adaptive laboratory evolution (ALE) studies play a crucial role in understanding
the adaptation and evolution of different bacterial species. In this study, we have …

Objective Organic acids have a wide range of applications and have attracted the attention
of many industries, and their large-scale applications have led fermentation production to …

Due to the complexity of metabolic and regulatory networks in microorganisms, it is difficult
to obtain robust phenotypes through artificial rational design and genetic perturbation …

The study of how micro-organisms detect and respond to different stresses has a long
history of producing fundamental biological insights while being simultaneously of …

Background During fermentation, industrial microorganisms encounter multiple stresses that
inhibit cell growth and decrease fermentation yields, in particular acid stress, which is due to …