Medication-overuse headache (MOH) is defined by the International Classification of
Headache Disorders as a headache in patients with a pre-existing primary headache …

Abstract The neurotransmitter serotonin (5-HT) plays a central role in brain development,
regulation of mood, stress reactivity and risk of psychiatric disorders, and thus alterations in …

Understanding the underlying mechanisms of the human brain in health and disease will
require models with necessary and sufficient details to explain how function emerges from …

Brain-derived neurotrophic factor (BDNF) has a primary role in neuronal development,
differentiation and plasticity in both the developing and adult brain. A single-nucleotide …

Converging evidence indicates an association of the short (s), low-expressing variant of the
repeat length polymorphism, serotonin transporter-linked polymorphic region (5-HTTLPR) …

In the last decade the serotonin transporter gene promoter polymorphism (5-HTTLPR) was
likely the most studied genetic variant as predictor of antidepressant response. Nevertheless …

Evidence that psychoactive substance use disorders, bulimia nervosa, pathological
gambling, and sexual addiction share an underlying biopsychological process is …

Childhood adversities have been associated with onset and worse clinical presentations of
depression. Epigenetic changes may reflect childhood adversities, while their effects on …

The serotonin transporter gene promoter polymorphism (5-HTTLPR) has been repeatedly
associated with antidepressant response in mood disorder patients, but findings are not …

Emerging research implicates a consistent reciprocal relationship between late-life anxiety
and cognition. Understanding this relationship may clarify pathophysiological substrates of …