The nitric oxide pathway plays a critical role in vascular homeostasis. Increased levels of
systemic nitric oxide (NO) are observed in preclinical models of sepsis and endotoxemia …

Meta-analyses and several large cohort studies have demonstrated that antiseptic
mouthwashes are associated with mortality in hospitalized patients. A clear pathogenic …

BACKGROUND Necrotizing soft-tissue infections (NSTIs) are rapidly progressing infections
frequently complicated by septic shock and associated with high mortality. Early diagnosis is …

Human sepsis is the result of a multifaceted pathological process causing marked
dysregulation of cardiovascular responses. A more sophisticated understanding of the …

ABSTRACT Group A Streptococcus (GAS) is a versatile pathogen that targets human
lymphoid, decidual, skin, and soft tissues. Recent advancements have shed light on its …

Necrotizing soft-tissue infection (NSTI) is a rare, severe, and fast-progressing bacterial
infection associated with a high risk of developing sepsis or septic shock. Increasing …

In necrotizing soft tissue infection (NSTI) there is a need to identify biomarker sets that can
be used for diagnosis and disease management. The INFECT study was designed to obtain …

Introduction: Blood levels of uremic toxin, asymmetric dimethylarginine (ADMA), are strongly
associated with mortality in sepsis, renal failure, and cardiovascular and renal disease …

Results: 334 studies were identified; after removing duplicates, 318 of them remained for
selection by titles and abstracts. At this stage, 235 studies were excluded as they did not …

Results: Eleven of 1342 studies were included in the review. The first of them was published
in 2017 and the last in 2022. Most of them were developed in the USA, China, and Germany …