Mass spectrometry is unmatched in its versatility for studying practically any aspect of the
proteome. Because the foundations of mass spectrometry-based proteomics are complex …

The E4 allele of Apolipoprotein E (APOE) is associated with both metabolic dysfunction and
a heightened pro-inflammatory response: two findings that may be intrinsically linked …

The exploration of protein structure and function stands at the forefront of life science and
represents an ever‐expanding focus in the development of proteomics. As mass …

BACKGROUND: The adult mammalian heart is incapable of regeneration, whereas a
transient regenerative capacity is maintained in the neonatal heart, primarily through the …

Research into how the young and old differ, and which biomarkers reflect the diverse
biological processes underlying ageing, is a current and fast-growing field. Biological clocks …

The multiple hypothesis testing problem is inherent in large-scale quantitative “omic”
experiments such as mass spectrometry-based proteomics. Yet, tools for comparing the …

The brain's neuroreparative capacity after injuries such as ischemic stroke is partly
contained in the brain's neurogenic niches, primarily the subventricular zone (SVZ), which …

Aging is associated with progressive phenotypic changes. Virtually all cellular phenotypes
are produced by proteins, and their structural alterations can lead to age-related diseases …

Here, we present FLiPPR, or FragPipe LiP (limited proteolysis) Processor, a tool that
facilitates the analysis of data from limited proteolysis mass spectrometry (LiP-MS) …

GoDig, a platform for targeted pathway proteomics without the need for manual assay
scheduling or synthetic standards, is a powerful, flexible, and easy-to-use method that uses …