Due to the structure of acylhydrazones both by the pharmacophore–CO–NH–N= group and
by the different substituents present in the molecules of compounds of this class, various …

Protein-directed dynamic combinatorial chemistry (PD DCC) is considered a powerful
strategy to identify ligands to pharmacologically relevant protein targets. The protein selects …

The acylhydrazone unit is well represented in screening databases used to find ligands for
biological targets, and numerous bioactive acylhydrazones have been reported. However …

Target-directed dynamic combinatorial chemistry (tdDCC) enables identification, as well as
optimization of ligands for un (der) explored targets such as the anti-infective target 1-deoxy …

Dramatic improvements in cancer survival have occurred in the last decade, but the quality
of life for many survivors is compromised due to severe, long-lasting, and often irreversible …

Dynamic combinatorial chemistry applied to biological environments requires the exchange
chemistry of choice to take place under physiological conditions. Thiol-disulfide exchange …

Target‐directed dynamic combinatorial chemistry has emerged as a useful tool for hit
identification, but has not been widely used, in part due to challenges associated with …

Sialic acids are part of the outermost component of the glycocalyx of all vertebrates; as such,
they are fundamental markers in physiological and pathological processes. In this study, we …

Heparin-like macromolecules are widely used in clinics as anticoagulant, antiviral, and
anticancer drugs. However, the search of heparin antidotes based on small synthetic …

Abstract Calcium (Ca2+) signaling is critical for neuronal functioning and requires the
concerted interplay of numerous Ca2+-binding proteins, including neuronal calcium sensor …