POxload: Machine Learning Estimates Drug Loadings of Polymeric Micelles
Block copolymers, composed of poly (2-oxazoline) s and poly (2-oxazine) s, can serve as
drug delivery systems; they form micelles that carry poorly water-soluble drugs. Many recent …
drug delivery systems; they form micelles that carry poorly water-soluble drugs. Many recent …
Molecular dynamics simulations of self-assembling colloids in fed-state human intestinal fluids and their solubilization of lipophilic drugs
Bioavailability of oral drugs often depends on how soluble the active pharmaceutical
ingredient is in the fluid present in the small intestine. For efficient drug discovery and …
ingredient is in the fluid present in the small intestine. For efficient drug discovery and …
Bile Is a Selective Elevator for Mucosal Mechanics and Transport
S Hanio, S Möllmert, C Möckel… - Molecular …, 2023 - ACS Publications
Mucus mechanically protects the intestinal epithelium and impacts the absorption of drugs,
with a largely unknown role for bile. We explored the impacts of bile on mucosal …
with a largely unknown role for bile. We explored the impacts of bile on mucosal …
Structural Investigation on How Guest Loading of Poly (2-oxazoline)-Based Micelles Affects the Interaction with Simulated Intestinal Fluids
S Endres, S Ehrmanntraut, L Endres… - ACS Biomaterials …, 2023 - ACS Publications
Drug loading of polymer micelles can have a profound effect on their particle size and
morphology as well as their physicochemical properties. In turn, this influences performance …
morphology as well as their physicochemical properties. In turn, this influences performance …
Exploring molecular fingerprints of different drugs having bile interaction: a stepping stone towards better drug delivery
Bile acids are amphiphilic substances produced naturally in humans. In the context of drug
delivery and dosage form design, it is critical to understand whether a drug interacts with bile …
delivery and dosage form design, it is critical to understand whether a drug interacts with bile …