Chronic wounds are characterized by their inability to heal within an expected time frame
and have emerged as an increasingly important clinical problem over the past several …

As the most dominant cell type in the skin, keratinocytes play critical roles in wound repair
not only as structural cells but also exerting important immune functions. This review focuses …

The skin is a complex organ that has devised numerous strategies, such as physical,
chemical, and microbiological barriers, to protect the host from external insults. In addition …

The ability to rapidly restore the integrity of a broken skin barrier is critical and is the ultimate
goal of therapies for hard-to-heal-ulcers. Unfortunately effective treatments to enhance …

The cellular and molecular mechanisms underpinning tissue repair and its failure to heal are
still poorly understood, and current therapies are limited. Poor wound healing after trauma …

Significance: Keratinocytes, a major cellular component of the epidermis, are responsible for
restoring the epidermis after injury through a process termed epithelialization. This review …

In this review, we describe current and future potential wound healing treatments for acute
and chronic wounds. The current wound healing approaches are based on autografts …

Background: As the population grows older, the incidence and prevalence of conditions that
lead to a predisposition for poor wound healing also increase. Ultimately, this increase in …

Abstract Purpose of Review Diabetic foot ulcerations (DFU) affect 25% of patients with
diabetes mellitus during their lifetime and constitute a major health problem as they are often …

The skin is the largest organ of the body and has an array of functions. Skin compartments,
epidermis, and hair follicles house stem cells that are indispensable for skin homeostasis …