The structural basis of function in Cys-loop receptors
AJ Thompson, HA Lester… - Quarterly reviews of …, 2010 - cambridge.org
Cys-loop receptors are membrane-spanning neurotransmitter-gated ion channels that are
responsible for fast excitatory and inhibitory transmission in the peripheral and central …
responsible for fast excitatory and inhibitory transmission in the peripheral and central …
Binding, activation and modulation of Cys-loop receptors
PS Miller, TG Smart - Trends in pharmacological sciences, 2010 - cell.com
It is over forty years since the major neurotransmitters and their protein receptors were
identified, and over twenty years since determination of the first amino-acid sequences of the …
identified, and over twenty years since determination of the first amino-acid sequences of the …
X-ray structure of the mouse serotonin 5-HT3 receptor
G Hassaine, C Deluz, L Grasso, R Wyss, MB Tol… - Nature, 2014 - nature.com
Neurotransmitter-gated ion channels of the Cys-loop receptor family mediate fast
neurotransmission throughout the nervous system. The molecular processes of …
neurotransmission throughout the nervous system. The molecular processes of …
Conformational transitions of the serotonin 5-HT3 receptor
L Polovinkin, G Hassaine, J Perot, E Neumann… - Nature, 2018 - nature.com
The serotonin 5-HT3 receptor is a pentameric ligand-gated ion channel (pLGIC). It belongs
to a large family of receptors that function as allosteric signal transducers across the plasma …
to a large family of receptors that function as allosteric signal transducers across the plasma …
The cellular, molecular and ionic basis of GABAA receptor signalling
GABA A receptors mediate fast synaptic inhibition in the CNS. Whilst this is undoubtedly
true, it is a gross oversimplification of their actions. The receptors themselves are diverse …
true, it is a gross oversimplification of their actions. The receptors themselves are diverse …
Principal pathway coupling agonist binding to channel gating in nicotinic receptors
WY Lee, SM Sine - Nature, 2005 - nature.com
Synaptic receptors respond to neurotransmitters by opening an intrinsic ion channel in the
final step in synaptic transmission. How binding of the neurotransmitter is conveyed over the …
final step in synaptic transmission. How binding of the neurotransmitter is conveyed over the …
Cannabinoid potentiation of glycine receptors contributes to cannabis-induced analgesia
W Xiong, KJ Cheng, T Cui, G Godlewski… - Nature chemical …, 2011 - nature.com
Cannabinoids enhance the function of glycine receptors (GlyRs). However, little is known
about the mechanisms and behavioral implication of cannabinoid-GlyR interaction. Using …
about the mechanisms and behavioral implication of cannabinoid-GlyR interaction. Using …
Synaptic neurotransmitter-gated receptors
TG Smart, P Paoletti - Cold Spring Harbor perspectives …, 2012 - cshperspectives.cshlp.org
Since the discovery of the major excitatory and inhibitory neurotransmitters and their
receptors in the brain, many have deliberated over their likely structures and how these may …
receptors in the brain, many have deliberated over their likely structures and how these may …
Additional acetylcholine (ACh) binding site at α4/α4 interface of (α4β2) 2α4 nicotinic receptor influences agonist sensitivity
S Mazzaferro, N Benallegue, A Carbone… - Journal of Biological …, 2011 - ASBMB
Nicotinic acetylcholine receptor (nAChR) α4 and β2 subunits assemble in two alternate
stoichiometries to produce (α4β2) 2 α4 and (α4β2) 2 β2, which display different agonist …
stoichiometries to produce (α4β2) 2 α4 and (α4β2) 2 β2, which display different agonist …
Number and locations of agonist binding sites required to activate homomeric Cys-loop receptors
D Rayes, MJ De Rosa, SM Sine… - Journal of …, 2009 - Soc Neuroscience
Homo-pentameric Cys-loop receptors contain five identical agonist binding sites, each
formed at a subunit interface. To determine the number and locations of binding sites …
formed at a subunit interface. To determine the number and locations of binding sites …