The properties of high-dimensional data spaces: implications for exploring gene and protein expression data
High-throughput genomic and proteomic technologies are widely used in cancer research to
build better predictive models of diagnosis, prognosis and therapy, to identify and …
build better predictive models of diagnosis, prognosis and therapy, to identify and …
The advantages of the Matthews correlation coefficient (MCC) over F1 score and accuracy in binary classification evaluation
Background To evaluate binary classifications and their confusion matrices, scientific
researchers can employ several statistical rates, accordingly to the goal of the experiment …
researchers can employ several statistical rates, accordingly to the goal of the experiment …
Data integration and predictive modeling methods for multi-omics datasets
M Kim, I Tagkopoulos - Molecular omics, 2018 - pubs.rsc.org
Translating data to knowledge and actionable insights is the Holy Grail for many scientific
fields, including biology. The unprecedented massive and heterogeneous data have created …
fields, including biology. The unprecedented massive and heterogeneous data have created …
Intratumoral and peritumoral radiomics for the pretreatment prediction of pathological complete response to neoadjuvant chemotherapy based on breast DCE-MRI
NM Braman, M Etesami, P Prasanna, C Dubchuk… - Breast Cancer …, 2017 - Springer
Background In this study, we evaluated the ability of radiomic textural analysis of
intratumoral and peritumoral regions on pretreatment breast cancer dynamic contrast …
intratumoral and peritumoral regions on pretreatment breast cancer dynamic contrast …
Machine learning-based analysis of MR multiparametric radiomics for the subtype classification of breast cancer
T Xie, Z Wang, Q Zhao, Q Bai, X Zhou, Y Gu… - Frontiers in …, 2019 - frontiersin.org
Objective: To investigate whether machine learning analysis of multiparametric MR
radiomics can help classify immunohistochemical (IHC) subtypes of breast cancer. Study …
radiomics can help classify immunohistochemical (IHC) subtypes of breast cancer. Study …
[HTML][HTML] Strategies to design clinical studies to identify predictive biomarkers in cancer research
JL Perez-Gracia, MF Sanmamed, A Bosch… - Cancer Treatment …, 2017 - Elsevier
The discovery of reliable biomarkers to predict efficacy and toxicity of anticancer drugs
remains one of the key challenges in cancer research. Despite its relevance, no efficient …
remains one of the key challenges in cancer research. Despite its relevance, no efficient …
Predictive value of quantitative 18F-FDG-PET radiomics analysis in patients with head and neck squamous cell carcinoma
Background Radiomics is aimed at image-based tumor phenotyping, enabling application
within clinical-decision-support-systems to improve diagnostic accuracy and allow for …
within clinical-decision-support-systems to improve diagnostic accuracy and allow for …
Use of natural language processing in electronic medical records to identify pregnant women with suicidal behavior: towards a solution to the complex classification …
We developed algorithms to identify pregnant women with suicidal behavior using
information extracted from clinical notes by natural language processing (NLP) in electronic …
information extracted from clinical notes by natural language processing (NLP) in electronic …
Predicting the hepatocarcinogenic potential of alkenylbenzene flavoring agents using toxicogenomics and machine learning
SS Auerbach, RR Shah, D Mav, CS Smith… - Toxicology and applied …, 2010 - Elsevier
Identification of carcinogenic activity is the primary goal of the 2-year bioassay. The expense
of these studies limits the number of chemicals that can be studied and therefore chemicals …
of these studies limits the number of chemicals that can be studied and therefore chemicals …
Proteomics and phosphoproteomics in precision medicine: applications and challenges
G Giudice, E Petsalaki - Briefings in bioinformatics, 2019 - academic.oup.com
Recent advances in proteomics allow the accurate measurement of abundances for
thousands of proteins and phosphoproteins from multiple samples in parallel. Therefore, for …
thousands of proteins and phosphoproteins from multiple samples in parallel. Therefore, for …