[HTML][HTML] A focused review on CB2 receptor-selective pharmacological properties and therapeutic potential of β-caryophyllene, a dietary cannabinoid
The endocannabinoid system (ECS), a conserved physiological system emerged as a novel
pharmacological target for its significant role and potential therapeutic benefits ranging from …
pharmacological target for its significant role and potential therapeutic benefits ranging from …
Cannabinoids: current and future options to treat chronic and chemotherapy-induced neuropathic pain
HL Blanton, J Brelsfoard, N DeTurk, K Pruitt… - Drugs, 2019 - Springer
Increases in cancer diagnosis have tremendous negative impacts on patients and their
families, and major societal and economic costs. The beneficial effect of chemotherapeutic …
families, and major societal and economic costs. The beneficial effect of chemotherapeutic …
Chronic cannabinoid receptor 2 activation reverses paclitaxel neuropathy without tolerance or cannabinoid receptor 1–dependent withdrawal
L Deng, J Guindon, BL Cornett, A Makriyannis… - Biological …, 2015 - Elsevier
Background Mixed cannabinoid receptor 1 and 2 (CB 1 and CB 2) agonists such as Δ 9-
tetrahydrocannabinol (Δ 9-THC) can produce tolerance, physical withdrawal, and unwanted …
tetrahydrocannabinol (Δ 9-THC) can produce tolerance, physical withdrawal, and unwanted …
Cannabinoid receptor activation potential of the next generation, generic ban evading OXIZID synthetic cannabinoid receptor agonists
MH Deventer, K Van Uytfanghe… - Drug Testing and …, 2022 - Wiley Online Library
In recent years, several nations have implemented various measures to control the surge of
new synthetic cannabinoid receptor agonists (SCRAs) entering the recreational drug market …
new synthetic cannabinoid receptor agonists (SCRAs) entering the recreational drug market …
Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: effects of endocannabinoid deactivation inhibitors targeting fatty-acid …
J Guindon, Y Lai, SM Takacs, HB Bradshaw… - Pharmacological …, 2013 - Elsevier
Cisplatin, a platinum-derived chemotherapeutic agent, produces mechanical and
coldallodynia reminiscent of chemotherapy-induced neuropathy in humans. The …
coldallodynia reminiscent of chemotherapy-induced neuropathy in humans. The …
Identification of AD‐18, 5F‐MDA‐19, and pentyl MDA‐19 in seized materials after the class‐wide ban of synthetic cannabinoids in China
CM Liu, ZD Hua, W Jia, T Li - Drug Testing and Analysis, 2022 - Wiley Online Library
To curb the manufacturing, trafficking, and abuse of synthetic cannabinoids, China
implemented a class‐wide regulation on synthetic cannabinoids in July 2021. Recently …
implemented a class‐wide regulation on synthetic cannabinoids in July 2021. Recently …
The oral administration of trans-caryophyllene attenuates acute and chronic pain in mice
L Paula-Freire, ML Andersen, VS Gama, GR Molska… - Phytomedicine, 2014 - Elsevier
Trans-caryophyllene is a sesquiterpene present in many medicinal plants' essential oils,
such as Ocimum gratissimum and Cannabis sativa. In this study, we evaluated the …
such as Ocimum gratissimum and Cannabis sativa. In this study, we evaluated the …
[HTML][HTML] Targeting peripherally restricted cannabinoid receptor 1, cannabinoid receptor 2, and endocannabinoid-degrading enzymes for the treatment of neuropathic …
MZ Hossain, H Ando, S Unno, J Kitagawa - International journal of …, 2020 - mdpi.com
Neuropathic pain conditions including neuropathic orofacial pain (NOP) are difficult to treat.
Contemporary therapeutic agents for neuropathic pain are often ineffective in relieving pain …
Contemporary therapeutic agents for neuropathic pain are often ineffective in relieving pain …
Cannabinoid agonist WIN 55,212-2 prevents the development of paclitaxel-induced peripheral neuropathy in rats. Possible involvement of spinal glial cells
E Burgos, D Gómez-Nicola, D Pascual, MI Martín… - European journal of …, 2012 - Elsevier
Spinal glial activation contributes to the development and maintenance of chronic pain
states, including neuropathic pain of diverse etiologies. Cannabinoid compounds have …
states, including neuropathic pain of diverse etiologies. Cannabinoid compounds have …
Update on cannabis and cannabinoids for cancer pain
To date, preclinical data has demonstrated evidence to suggest promising potential for
cancer pain and the urgent need to translate this into clinical practice. Unfortunately, due to …
cancer pain and the urgent need to translate this into clinical practice. Unfortunately, due to …