The endocannabinoid system (ECS), a conserved physiological system emerged as a novel
pharmacological target for its significant role and potential therapeutic benefits ranging from …

Increases in cancer diagnosis have tremendous negative impacts on patients and their
families, and major societal and economic costs. The beneficial effect of chemotherapeutic …

Background Mixed cannabinoid receptor 1 and 2 (CB 1 and CB 2) agonists such as Δ 9-
tetrahydrocannabinol (Δ 9-THC) can produce tolerance, physical withdrawal, and unwanted …

In recent years, several nations have implemented various measures to control the surge of
new synthetic cannabinoid receptor agonists (SCRAs) entering the recreational drug market …

Cisplatin, a platinum-derived chemotherapeutic agent, produces mechanical and
coldallodynia reminiscent of chemotherapy-induced neuropathy in humans. The …

To curb the manufacturing, trafficking, and abuse of synthetic cannabinoids, China
implemented a class‐wide regulation on synthetic cannabinoids in July 2021. Recently …

Trans-caryophyllene is a sesquiterpene present in many medicinal plants' essential oils,
such as Ocimum gratissimum and Cannabis sativa. In this study, we evaluated the …

Neuropathic pain conditions including neuropathic orofacial pain (NOP) are difficult to treat.
Contemporary therapeutic agents for neuropathic pain are often ineffective in relieving pain …

Spinal glial activation contributes to the development and maintenance of chronic pain
states, including neuropathic pain of diverse etiologies. Cannabinoid compounds have …

To date, preclinical data has demonstrated evidence to suggest promising potential for
cancer pain and the urgent need to translate this into clinical practice. Unfortunately, due to …