In 2017, an autologous chimeric antigen receptor (CAR) T cell therapy indicated for children
and young adults with relapsed and/or refractory CD19+ acute lymphoblastic leukaemia …

BACKGROUND Germ cell depletion caused by chemical or physical toxicity, disease or
genetic predisposition can occur at any age. Although semen cryopreservation is the first …

Transplantation of hematopoietic stem cells (HSCs) has been successfully developed as a
part of treatment protocols for a large number of clinical indications, and cryopreservation of …

Stem cell transplantation represents a critical approach for the treatment of many malignant
and non‐malignant diseases. The foundation for these approaches is the ability to …

BACKGROUND Preservation of the male germ line in prepubertal boys undergoing
gonadotoxic treatment is a crucial consideration in terms of their future quality of life. As …

Cells and tissues are the foundation of translational medicine. At present, one of the main
technological obstacles is their preservation for long-term usage while maintaining …

Background: Dimethyl sulfoxide (DMSO) has been used for medical treatment and as a
pharmacological agent in humans since the 1960s. Today, DMSO is used mostly for …

Heat shock protein 90 (Hsp90) is an emerging therapeutic target of interest for the treatment
of cancer. Its role in protein homeostasis and the selective chaperoning of key signaling …

BACKGROUND Since prepubertal boys cannot benefit from sperm banking, a potential
alternative strategy for fertility preservation involves immature testicular tissue (ITT) banking …

The cryoprotectant dimethyl sulfoxide (DMSO) is known to have toxic side effects, yet
guidelines for its use in stem cell transplantation do not exist. To assess current practice in …