Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases
HK Eltzschig, DL Bratton, SP Colgan - Nature Reviews Drug Discovery, 2014 - nature.com
Hypoxia-inducible factors (HIFs) are stabilized during adverse inflammatory processes
associated with disorders such as inflammatory bowel disease, pathogen infection and …
associated with disorders such as inflammatory bowel disease, pathogen infection and …
Equilibrative nucleoside transporters—A review
RC Boswell-Casteel, FA Hays - Nucleosides, Nucleotides and …, 2017 - Taylor & Francis
Equilibrative nucleoside transporters (ENTs) are polytopic integral membrane proteins that
mediate the transport of nucleosides, nucleobases, and therapeutic analogs. The best …
mediate the transport of nucleosides, nucleobases, and therapeutic analogs. The best …
[HTML][HTML] Extracellular adenosine-mediated modulation of regulatory T cells
A Ohta, M Sitkovsky - Frontiers in immunology, 2014 - frontiersin.org
Extracellular adenosine-dependent suppression and redirection of pro-inflammatory
activities are mediated by the signaling through adenosine receptors on the surface of most …
activities are mediated by the signaling through adenosine receptors on the surface of most …
Purinergic signalling in brain ischemia
Ischemia is a multifactorial pathology characterized by different events evolving in the time.
After ischemia a primary damage due to the early massive increase of extracellular …
After ischemia a primary damage due to the early massive increase of extracellular …
Extracellular nucleotide and nucleoside signaling in vascular and blood disease
M Idzko, D Ferrari, AK Riegel… - Blood, The Journal of …, 2014 - ashpublications.org
Nucleotides and nucleosides—such as adenosine triphosphate (ATP) and adenosine—are
famous for their intracellular roles as building blocks for the genetic code or cellular energy …
famous for their intracellular roles as building blocks for the genetic code or cellular energy …
[HTML][HTML] The hypoxia-adenosine link during myocardial ischemia—reperfusion injury
Despite increasing availability and more successful interventional approaches to restore
coronary reperfusion, myocardial ischemia-reperfusion injury is a substantial cause of …
coronary reperfusion, myocardial ischemia-reperfusion injury is a substantial cause of …
Adenosine—a physiological or pathophysiological agent?
BB Fredholm - Journal of molecular medicine, 2014 - Springer
This minireview briefly summarizes the evidence that adenosine, acting on four G-protein
coupled receptors, can play physiological roles, but is also critically involved in pathological …
coupled receptors, can play physiological roles, but is also critically involved in pathological …
Transcriptional control of adenosine signaling by hypoxia-inducible transcription factors during ischemic or inflammatory disease
JM Poth, K Brodsky, H Ehrentraut, A Grenz… - Journal of molecular …, 2013 - Springer
Inflammatory lesions, ischemic tissues, or solid tumors are characterized by the occurrence
of severe tissue hypoxia within the diseased tissue. Subsequent stabilization of hypoxia …
of severe tissue hypoxia within the diseased tissue. Subsequent stabilization of hypoxia …
[HTML][HTML] Targeting myocardial equilibrative nucleoside transporter ENT1 provides cardioprotection by enhancing myeloid Adora2b signaling
Previous studies implicate extracellular adenosine signaling in attenuating myocardial
ischemia and reperfusion injury (IRI). This extracellular adenosine signaling is terminated by …
ischemia and reperfusion injury (IRI). This extracellular adenosine signaling is terminated by …
Targeting hypoxia signaling for perioperative organ injury
January 2018• Volume 126• Number 1 www. anesthesia-analgesia. org 309 targeted
therapeutically in patients as a potential treatment approach for the prevention or treatment …
therapeutically in patients as a potential treatment approach for the prevention or treatment …