Conspectus DNA is damaged by various endogenous and exogenous sources, leading to a
diverse group of reactive intermediates that yield a complex mixture of products. The initially …

Histones and many other proteins react with abundant endogenous DNA lesions,
apurinic/apyrimidinic (abasic, AP) sites and/or 3′-phospho-α, β-unsaturated aldehyde (3 …

Site‐specific introduction of bioorthogonal handles into RNAs is in high demand for
decorating RNAs with fluorophores, affinity labels or other modifications. Aldehydes …

The post‐translational modifications (PTMs) on the tail of histone H3 control chromatin
structure and influence epigenetics and gene expression. The current chemical methods …

Histones catalyze the DNA strand incision at apurinic/apyrimidinic (AP) sites accompanied
by formation of reversible but long-lived DNA–protein cross-links (DPCs) at 3′-DNA termini …

The focus of this work was the development and application of highly efficient RNA catalysts
for the site-specific modification of RNA with special focus on methylation. In the course of …

As central components of life, DNA and RNA encode the genetic information. However, RNA
performs several functions that exceed the competences stated in the 'central dogma of life ' …

DNA damage caused by alkylation and oxidation is harmful to cells, potentially leading to
cell death or cancer. Alkylating drugs and radiotherapy exploit this cytotoxicity to kill tumor …

Chromatin is vital to compaction and regulation of the DNA in eukaryotes and is intimately
involved in DNA expression, replication, and repair. As one of the cell's biggest polymers …