Low-intensity continuous ultrasound therapies—a systematic review of current state-of-the-art and future perspectives

SMZ Uddin, DE Komatsu, T Motyka… - Journal of clinical …, 2021 - mdpi.com
Therapeutic ultrasound has been studied for over seven decades for different medical
applications. The versatility of ultrasound applications are highly dependent on the …

Physical stimulations for bone and cartilage regeneration

X Huang, R Das, A Patel, T Duc Nguyen - Regenerative engineering and …, 2018 - Springer
A wide range of techniques and methods are actively invented by clinicians and scientists
who are dedicated to the field of musculoskeletal tissue regeneration. Biological, chemical …

Low‐intensity ultrasound stimulation enhances chondrogenic differentiation in alginate culture of mesenchymal stem cells

HJ Lee, BH Choi, BH Min, YS Son, SR Park - Artificial organs, 2006 - Wiley Online Library
Mesenchymal stem cells (MSCs) are regarded as a potential autologous source for cartilage
repair, because they can differentiate into chondrocytes by transforming growth factor‐beta …

Preconditioning of Mesenchymal Stem Cells with Low-Intensity Ultrasound for Cartilage Formation In Vivo

JH Cui, SR Park, K Park, BH Choi, B Min - Tissue engineering, 2007 - liebertpub.com
The purpose of this study was to evaluate the benefits of in vitro preconditioning of
mesenchymal stem cells (MSCs) using low-intensity ultrasound (US) in the induction of …

[HTML][HTML] Modification of osteoarthritis in the guinea pig with pulsed low-intensity ultrasound treatment

I Gurkan, A Ranganathan, X Yang, WE Horton Jr… - Osteoarthritis and …, 2010 - Elsevier
OBJECTIVE: The Hartley guinea pig develops articular cartilage degeneration similar to that
seen in idiopathic human osteoarthritis (OA). We investigated whether the application of …

Drugs and polymers for delivery systems in OA joints: Clinical needs and opportunities

M Janssen, G Mihov, T Welting, J Thies, P Emans - Polymers, 2014 - mdpi.com
Osteoarthritis (OA) is a big burden of disease worldwide and one of the most common
causes of disability in the adult population. Currently applied therapies consist of physical …

Low‐intensity ultrasound stimulates the viability and matrix gene expression of human articular chondrocytes in alginate bead culture

BH Choi, JI Woo, BH Min… - Journal of Biomedical …, 2006 - Wiley Online Library
We investigated the effects of low‐intensity ultrasound (LIUS) on the activity of human
articular chondrocytes isolated from osteoarthritis patients and cultured in the three …

Low-intensity ultrasound inhibits apoptosis and enhances viability of human mesenchymal stem cells in three-dimensional alginate culture during chondrogenic …

HJ Lee, BH Choi, BH Min, SR Park - Tissue Engineering, 2007 - liebertpub.com
Many studies have investigated optimal chondrogenic conditions, but only a few of them
have addressed their effects on cell viability or the methods to enhance it. This study …

Focused low-intensity pulsed ultrasound affects extracellular matrix degradation via decreasing chondrocyte apoptosis and inflammatory mediators in a surgically …

L Jia, J Chen, Y Wang, Y Zhang, W Chen - Ultrasound in Medicine & …, 2016 - Elsevier
We investigated whether focused low-intensity pulsed ultrasound (FLIPUS) affects
extracellular matrix (ECM) production in osteoarthritic (OA) rabbits by decreasing …

Sustained acoustic medicine; sonophoresis for nonsteroidal anti-inflammatory drug delivery in arthritis

J Masterson, B Kluge, A Burdette, GL Sr - Therapeutic Delivery, 2020 - Taylor & Francis
Background: Arthritis pain is primarily managed by nonsteroidal anti-inflammatory drugs
(NSAIDs), such as diclofenac. Topical diclofenac gel is limited in efficacy due to its limited …