Bioorthogonal transition metal catalysts (TMCs) transform therapeutically inactive molecules
(pro-drugs) into active drug compounds. Inorganic nanoscaffolds protect and solubilize …

Bioorthogonal chemistry is a promising toolbox for dissecting biological processes in the
native environment. Recently, bioorthogonal reactions have attracted considerable attention …

Considering the intrinsic toxicities of transition metals, their incorporation into drug therapies
must operate at minimal amounts while ensuring adequate catalytic activity within complex …

The incorporation of abiotic transition metal catalysis into the chemical biology space has
significantly expanded the tool kit of bioorthogonal chemistries accessible for cell culture …

Bioorthogonal chemistry, referring to chemical reactions occurring in a physiological
environment without interfering with native biochemical reactions, has witnessed substantial …

An emerging approach in the field of targeted drug delivery is the establishment of abiotic
metal‐triggered prodrug mechanisms that can control the release of bioactive drugs …

The site-specific delivery of antitumor agents is a rapidly developing field that relies on
prodrug activation and uncaging strategies. For this purpose, a wide range of homogeneous …

Metal-based uncaging of biomolecules has become an emerging approach for in vivo
applications, which is largely due to the advantageous bioorthogonality of abiotic transition …

Bioorthogonal prodrug activation is fascinating but suffers from staggered administration of
prodrug and trigger, which would not only reduce the therapeutic effect but bring great …

Bioorthogonal chemistry has inspired a new subarea of chemistry providing a powerful tool
to perform novel biocompatible chemospecific reactions in living systems. Following the …