CD8+ T cell metabolism in infection and cancer
M Reina-Campos, NE Scharping… - Nature Reviews …, 2021 - nature.com
Cytotoxic CD8+ T cells play a key role in the elimination of intracellular infections and
malignant cells and can provide long-term protective immunity. In the response to infection …
malignant cells and can provide long-term protective immunity. In the response to infection …
Metabolic coordination of T cell quiescence and activation
NM Chapman, MR Boothby, H Chi - Nature reviews immunology, 2020 - nature.com
Naive T cells are actively maintained in a quiescent state that promotes their survival and
persistence. On antigen stimulation, T cells exit quiescence to initiate clonal expansion and …
persistence. On antigen stimulation, T cells exit quiescence to initiate clonal expansion and …
Metabolic regulation of T cell longevity and function in tumor immunotherapy
RJ Kishton, M Sukumar, NP Restifo - Cell metabolism, 2017 - cell.com
Cancer immunotherapy is an increasingly successful strategy for the treatment of patients
who have advanced or conventional therapy-resistant cancers. T cells are key mediators of …
who have advanced or conventional therapy-resistant cancers. T cells are key mediators of …
T cell metabolism drives immunity
Lymphocytes must adapt to a wide array of environmental stressors as part of their normal
development, during which they undergo a dramatic metabolic remodeling process …
development, during which they undergo a dramatic metabolic remodeling process …
Integrative proteomics and phosphoproteomics profiling reveals dynamic signaling networks and bioenergetics pathways underlying T cell activation
The molecular circuits by which antigens activate quiescent T cells remain poorly
understood. We combined temporal profiling of the whole proteome and phosphoproteome …
understood. We combined temporal profiling of the whole proteome and phosphoproteome …
Signaling networks in immunometabolism
Adaptive immunity is essential for pathogen and tumor eradication, but may also trigger
uncontrolled or pathological inflammation. T cell receptor, co-stimulatory and cytokine …
uncontrolled or pathological inflammation. T cell receptor, co-stimulatory and cytokine …
mTORC1 and mTORC2 selectively regulate CD8+ T cell differentiation
Activation of mTOR-dependent pathways regulates the specification and differentiation of
CD4+ T effector cell subsets. Herein, we show that mTOR complex 1 (mTORC1) and …
CD4+ T effector cell subsets. Herein, we show that mTOR complex 1 (mTORC1) and …
Mitochondrial membrane potential identifies cells with enhanced stemness for cellular therapy
Long-term survival and antitumor immunity of adoptively transferred CD8+ T cells is
dependent on their metabolic fitness, but approaches to isolate therapeutic T cells based on …
dependent on their metabolic fitness, but approaches to isolate therapeutic T cells based on …
Metabolic and epigenetic coordination of T cell and macrophage immunity
Recognition of pathogens by innate and adaptive immune cells instructs rapid alterations of
cellular processes to promote effective resolution of infection. To accommodate increased …
cellular processes to promote effective resolution of infection. To accommodate increased …
mTOR regulation of glycolytic metabolism in T cells
RJ Salmond - Frontiers in cell and developmental biology, 2018 - frontiersin.org
T cell activation, differentiation and effector function is intrinsically linked to the regulation of
metabolic pathways. Evidence has shown that inflammatory T cell responses are dependent …
metabolic pathways. Evidence has shown that inflammatory T cell responses are dependent …