Cytotoxic CD8+ T cells play a key role in the elimination of intracellular infections and
malignant cells and can provide long-term protective immunity. In the response to infection …

Naive T cells are actively maintained in a quiescent state that promotes their survival and
persistence. On antigen stimulation, T cells exit quiescence to initiate clonal expansion and …

Cancer immunotherapy is an increasingly successful strategy for the treatment of patients
who have advanced or conventional therapy-resistant cancers. T cells are key mediators of …

Lymphocytes must adapt to a wide array of environmental stressors as part of their normal
development, during which they undergo a dramatic metabolic remodeling process …

The molecular circuits by which antigens activate quiescent T cells remain poorly
understood. We combined temporal profiling of the whole proteome and phosphoproteome …

Adaptive immunity is essential for pathogen and tumor eradication, but may also trigger
uncontrolled or pathological inflammation. T cell receptor, co-stimulatory and cytokine …

Activation of mTOR-dependent pathways regulates the specification and differentiation of
CD4+ T effector cell subsets. Herein, we show that mTOR complex 1 (mTORC1) and …

Long-term survival and antitumor immunity of adoptively transferred CD8+ T cells is
dependent on their metabolic fitness, but approaches to isolate therapeutic T cells based on …

Recognition of pathogens by innate and adaptive immune cells instructs rapid alterations of
cellular processes to promote effective resolution of infection. To accommodate increased …

T cell activation, differentiation and effector function is intrinsically linked to the regulation of
metabolic pathways. Evidence has shown that inflammatory T cell responses are dependent …