[HTML][HTML] Radiopharmaceutical therapy in cancer: clinical advances and challenges

G Sgouros, L Bodei, MR McDevitt… - Nature reviews Drug …, 2020 - nature.com
Radiopharmaceutical therapy (RPT) is emerging as a safe and effective targeted approach
to treating many types of cancer. In RPT, radiation is systemically or locally delivered using …

[HTML][HTML] Current status of theranostics in prostate cancer

I Virgolini, C Decristoforo, A Haug, S Fanti… - European journal of …, 2018 - Springer
The aim of this review is to report on the current status of prostate-specific membrane
antigen (PSMA)-directed theranostics in prostate cancer (PC) patients. The value of 68 Ga …

Targeted α-therapy of metastatic castration-resistant prostate cancer with 225Ac-PSMA-617: dosimetry estimate and empiric dose finding

C Kratochwil, F Bruchertseifer, H Rathke… - Journal of Nuclear …, 2017 - Soc Nuclear Med
The aim of this study was to develop a treatment protocol for 225Ac-PSMA-617 α-radiation
therapy in advanced-stage, metastatic castration-resistant prostate cancer patients with …

Targeted α-therapy of metastatic castration-resistant prostate cancer with 225Ac-PSMA-617: swimmer-plot analysis suggests efficacy regarding duration of tumor …

C Kratochwil, F Bruchertseifer, H Rathke… - Journal of Nuclear …, 2018 - Soc Nuclear Med
The aim of this evaluation was to identify the first indicators of efficacy for 225Ac-labeled
prostate-specific membrane antigen (PSMA)–617 therapy in a retrospectively analyzed …

Phase 1/2 study of fractionated dose lutetium‐177–labeled anti–prostate‐specific membrane antigen monoclonal antibody J591 (177Lu‐J591) for metastatic …

ST Tagawa, S Vallabhajosula, PJ Christos… - Cancer, 2019 - Wiley Online Library
Background Prostate cancer is radiosensitive. Prostate‐specific membrane antigen (PSMA)
is selectively overexpressed on advanced, castration‐resistant tumors. Lutetium‐177 …

Preclinical efficacy of a PSMA-targeted thorium-227 conjugate (PSMA-TTC), a targeted alpha therapy for prostate cancer

S Hammer, UB Hagemann, S Zitzmann-Kolbe… - Clinical Cancer …, 2020 - AACR
Purpose: Prostate-specific membrane antigen (PSMA) is an attractive target for radionuclide
therapy of metastatic castration-resistant prostate cancer (mCRPC). PSMA-targeted alpha …

225Ac-PSMA-617 for therapy of prostate cancer

C Kratochwil, U Haberkorn, FL Giesel - Seminars in nuclear medicine, 2020 - Elsevier
Prostate-specific membrane antigen (PSMA)-targeting radio-ligand therapy with beta-
emitting 177 Lutetium has already been investigated in several early phase dosimetry …

Alpha-emitters and targeted alpha therapy in oncology: from basic science to clinical investigations

M Makvandi, E Dupis, JW Engle, FM Nortier… - Targeted …, 2018 - Springer
Alpha-emitters are radionuclides that decay through the emission of high linear energy
transfer α-particles and possess favorable pharmacologic profiles for cancer treatment …

Targeting prostate cancer: prostate‐specific membrane antigen based diagnosis and therapy

T Wüstemann, U Haberkorn, J Babich… - Medicinal research …, 2019 - Wiley Online Library
The high incidence rates of prostate cancer (PCa) raise demand for improved therapeutic
strategies. Prostate tumors specifically express the prostate‐specific membrane antigen …

[HTML][HTML] Development of radiopharmaceuticals for targeted alpha therapy: Where do we stand?

RM Pallares, RJ Abergel - Frontiers in medicine, 2022 - frontiersin.org
Targeted alpha therapy is an oncological treatment, where cytotoxic doses of alpha radiation
are locally delivered to tumor cells, while the surrounding healthy tissue is minimally …