[HTML][HTML] Radiopharmaceutical therapy in cancer: clinical advances and challenges
Radiopharmaceutical therapy (RPT) is emerging as a safe and effective targeted approach
to treating many types of cancer. In RPT, radiation is systemically or locally delivered using …
to treating many types of cancer. In RPT, radiation is systemically or locally delivered using …
[HTML][HTML] Current status of theranostics in prostate cancer
The aim of this review is to report on the current status of prostate-specific membrane
antigen (PSMA)-directed theranostics in prostate cancer (PC) patients. The value of 68 Ga …
antigen (PSMA)-directed theranostics in prostate cancer (PC) patients. The value of 68 Ga …
Targeted α-therapy of metastatic castration-resistant prostate cancer with 225Ac-PSMA-617: dosimetry estimate and empiric dose finding
C Kratochwil, F Bruchertseifer, H Rathke… - Journal of Nuclear …, 2017 - Soc Nuclear Med
The aim of this study was to develop a treatment protocol for 225Ac-PSMA-617 α-radiation
therapy in advanced-stage, metastatic castration-resistant prostate cancer patients with …
therapy in advanced-stage, metastatic castration-resistant prostate cancer patients with …
Targeted α-therapy of metastatic castration-resistant prostate cancer with 225Ac-PSMA-617: swimmer-plot analysis suggests efficacy regarding duration of tumor …
C Kratochwil, F Bruchertseifer, H Rathke… - Journal of Nuclear …, 2018 - Soc Nuclear Med
The aim of this evaluation was to identify the first indicators of efficacy for 225Ac-labeled
prostate-specific membrane antigen (PSMA)–617 therapy in a retrospectively analyzed …
prostate-specific membrane antigen (PSMA)–617 therapy in a retrospectively analyzed …
Phase 1/2 study of fractionated dose lutetium‐177–labeled anti–prostate‐specific membrane antigen monoclonal antibody J591 (177Lu‐J591) for metastatic …
ST Tagawa, S Vallabhajosula, PJ Christos… - Cancer, 2019 - Wiley Online Library
Background Prostate cancer is radiosensitive. Prostate‐specific membrane antigen (PSMA)
is selectively overexpressed on advanced, castration‐resistant tumors. Lutetium‐177 …
is selectively overexpressed on advanced, castration‐resistant tumors. Lutetium‐177 …
Preclinical efficacy of a PSMA-targeted thorium-227 conjugate (PSMA-TTC), a targeted alpha therapy for prostate cancer
S Hammer, UB Hagemann, S Zitzmann-Kolbe… - Clinical Cancer …, 2020 - AACR
Purpose: Prostate-specific membrane antigen (PSMA) is an attractive target for radionuclide
therapy of metastatic castration-resistant prostate cancer (mCRPC). PSMA-targeted alpha …
therapy of metastatic castration-resistant prostate cancer (mCRPC). PSMA-targeted alpha …
225Ac-PSMA-617 for therapy of prostate cancer
C Kratochwil, U Haberkorn, FL Giesel - Seminars in nuclear medicine, 2020 - Elsevier
Prostate-specific membrane antigen (PSMA)-targeting radio-ligand therapy with beta-
emitting 177 Lutetium has already been investigated in several early phase dosimetry …
emitting 177 Lutetium has already been investigated in several early phase dosimetry …
Alpha-emitters and targeted alpha therapy in oncology: from basic science to clinical investigations
Alpha-emitters are radionuclides that decay through the emission of high linear energy
transfer α-particles and possess favorable pharmacologic profiles for cancer treatment …
transfer α-particles and possess favorable pharmacologic profiles for cancer treatment …
Targeting prostate cancer: prostate‐specific membrane antigen based diagnosis and therapy
T Wüstemann, U Haberkorn, J Babich… - Medicinal research …, 2019 - Wiley Online Library
The high incidence rates of prostate cancer (PCa) raise demand for improved therapeutic
strategies. Prostate tumors specifically express the prostate‐specific membrane antigen …
strategies. Prostate tumors specifically express the prostate‐specific membrane antigen …
[HTML][HTML] Development of radiopharmaceuticals for targeted alpha therapy: Where do we stand?
RM Pallares, RJ Abergel - Frontiers in medicine, 2022 - frontiersin.org
Targeted alpha therapy is an oncological treatment, where cytotoxic doses of alpha radiation
are locally delivered to tumor cells, while the surrounding healthy tissue is minimally …
are locally delivered to tumor cells, while the surrounding healthy tissue is minimally …