Since the first discovery of Kvβ-subunits more than 15 years ago, many more ancillary Kv
channel subunits were characterized, for example, KChIPs, KCNEs, and BKβ-subunits. The …

The patch-clamp technique represents an electrophysiology type of method. This is one of
several insightful approaches with five major configurations, namely a loose patch, cell …

KV channel-interacting proteins (KChIP1-4) belong to a family of Ca2+-binding EF-hand
proteins that are able to bind to the N-terminus of the KV4 channel α-subunits. KChIPs are …

Background: Purkinje fibers (PFs) control timing of ventricular conduction and play a key role
in arrhythmogenesis in heart failure (HF) patients. We investigated the effects of HF on PFs …

Complex modulation of voltage-gated Ca2+ currents through the interplay among Ca2+
channels and various Ca2+-binding proteins is increasingly being recognized. The K+ …

Background: KChIP2 (K+ channel interacting protein) is the auxiliary subunit of the fast
transient outward K+ current (I to, f) in the heart, and insufficient KChIP2 expression induces …

Notch receptor signaling is active during cardiac development and silenced in myocytes
after birth. Conversely, outward K+ Kv currents progressively appear in postnatal myocytes …

Key points• The cytosolic K+ channel accessory subunit, K+ channel interacting protein 2
(KChIP2), was previously suggested to be critical in the generation of cardiac fast transient …

Recent evidence shows that the auxiliary subunit KChIP2, which assembles with pore-
forming Kv4-subunits, represents a new potential regulator of the cardiac calcium …

Transient outward K+ current (Ito) plays a crucial role in the early phase of cardiac action
potential repolarization. Kv4. 3 K+ channel is an important component of Ito. The function …