Although sugars are clearly the preferred carbon sources of the yeast Saccharomyces
cerevisiae, nonfermentable substrates such as ethanol, glycerol, lactate, acetate or oleate …

The essential role of peroxisomes in fatty acid oxidation, anaplerotic metabolism, and
hydrogen peroxide turnover is well established. Recent findings suggest that these and …

Mitochondrial dysfunction can lead to diverse cellular and organismal responses. We used
DNA microarrays to characterize the transcriptional responses to different mitochondrial …

Cells modulate the expression of nuclear genes in response to changes in the functional
state of mitochondria, an interorganelle communication pathway called retrograde …

De novo biosynthesis of amino acids uses intermediates provided by the TCA cycle that
must be replenished by anaplerotic reactions to maintain the respiratory competency of the …

The expression of some nuclear genes in Saccharomyces cerevisiae, such as the CIT2
gene, which encodes a glyoxylate cycle isoform of citrate synthase, is responsive to the …

Exogenous long-chain fatty acids are activated to coenzyme A derivatives prior to metabolic
utilization. In the yeastSaccharomyces cerevisiae, the activation of these compounds prior to …

Jodi Nunnari* and Peter Walter an organism are compared. In mammals, for example, the
ER is vastly abundant in exocrine pancreatic secre-Department of Biochemistry and …

In the yeast Saccharomyces cerevisiae, expression of some nuclear genes is modulated in
response to changes in the functional state of mitochondria (Butow et al., 1988; Parikh et al …

Unicellular organisms such as yeast constantly monitor their environment and respond to
nutritional cues. Rapid adaptation to ambient changes may include modification and …