One of the long-standing goals of both researchers and oncologists is to establish a
framework for the complete cure of cancer with less toxic adverse effect and improved …

Background Fluorescence-guided surgery (FGS) is a technique used to enhance
visualization of tumor margins in order to increase the extent of tumor resection in glioma …

Object The extent of resection (EOR) is a known prognostic factor in patients with
glioblastoma. However, gross-total resection (GTR) is not always achieved. Understanding …

Importance High-grade gliomas (HGG) are the most aggressive and common malignant
brain tumors in adults. They have a dismally fatal prognosis. Even if gross total resection of …

We analyzed the efficacy and applicability of surgery guided by 5-aminolevulinic acid (ALA)
fluorescence in consecutive patients with glioblastoma multiforme (GBM). Thirty-six patients …

BACKGROUND: Complete resection of contrast-enhancing tumor has been recognized as
an important prognostic factor in patients with glioblastoma and is a primary goal of surgery …

Object Mapping and monitoring are believed to provide an early warning sign to determine
when to stop tumor removal to avoid mechanical damage to the corticospinal tract (CST) …

BACKGROUND: There is evidence in the literature supporting that fluorescent tissue signal
in fluorescence-guided surgery extends farther than tissue highlighted in gadolinium in T1 …

Objective Fluorescence guidance has a demonstrated potential in maximizing the extent of
high-grade glioma resection. Different fluorophores (fluorescent biomarkers), including 5 …

Glioblastoma multiforme is the most common primary malignant tumor of the central nervous
system. Despite new insights into glioblastoma pathophysiology, the prognosis for patients …