NLRP3 inflammasome in cancer and metabolic diseases

BR Sharma, TD Kanneganti - Nature immunology, 2021 - nature.com
The NLRP3 inflammasome is a multimeric cytosolic protein complex that assembles in
response to cellular perturbations. This assembly leads to the activation of caspase-1, which …

Inflammasome signaling in colorectal cancer

BR Sharma, TD Kanneganti - Translational Research, 2023 - Elsevier
Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths in the world.
Inflammation is often an underlying risk factor for developing CRC. Maintaining gut …

Blueberry and blackberry anthocyanins ameliorate metabolic syndrome by modulating gut microbiota and short-chain fatty acids metabolism in high-fat diet-fed C57BL …

L Du, H Lü, Y Chen, X Yu, T Jian, H Zhao… - Journal of Agricultural …, 2023 - ACS Publications
In this study, blueberry (Vaccinium ssp.) anthocyanins (VA) and blackberry (Rubus L.)
anthocyanins (RA) were used to investigate the effects on metabolic syndrome (MetS) and …

Wumei Pill Ameliorates AOM/DSS‐Induced Colitis‐Associated Colon Cancer through Inhibition of Inflammation and Oxidative Stress by Regulating S …

J Wang, K Ding, Y Wang, T Yan, Y Xu… - Oxidative Medicine …, 2022 - Wiley Online Library
Wumei Pill (WMP) is a traditional Chinese herbal formulation and widely used to treat
digestive system diseases in clinical. S‐Adenosylhomocysteine hydrolase (AHCY) can …

Theabrownin alleviates colorectal tumorigenesis in murine AOM/DSS model via PI3K/Akt/mTOR pathway suppression and gut microbiota modulation

HKM Leung, EKK Lo, H El-Nezami - Antioxidants, 2022 - mdpi.com
Colorectal cancer (CRC) is one of the most common and fatal cancers worldwide, yet
therapeutic options for CRC often exhibit strong side effects which cause patients' well-being …

Fusobacterium nucleatum Accelerates the Progression of Colitis-Associated Colorectal Cancer by Promoting EMT

MR Yu, HJ Kim, HR Park - Cancers, 2020 - mdpi.com
Simple Summary Colitis-associated cancer (CAC) are associated with the development and
progression of colorectal cancer (CRC). And Fusobacterium nucleatum (F. nucleatum), a …

Improving silymarin oral bioavailability using silica-installed redox nanoparticle to suppress inflammatory bowel disease

THT Nguyen, NT Trinh, HN Tran, HT Tran, PQ Le… - Journal of controlled …, 2021 - Elsevier
Chronic inflammatory diseases such as inflammatory bowel diseases (IBD), which are
strongly related to the overproduction of reactive oxygen species (ROS), have become more …

Unveiling colitis: a journey through the dextran sodium sulfate-induced model

C Yang, D Merlin - Inflammatory Bowel Diseases, 2024 - academic.oup.com
Animal models of inflammatory bowel disease (IBD) are valuable tools for investigating the
factors involved in IBD pathogenesis and evaluating new therapeutic options. The dextran …

High-fat diet induced cyclophilin B enhances STAT3/lncRNA-PVT1 feedforward loop and promotes growth and metastasis in colorectal cancer

H Guo, K Zhuang, N Ding, R Hua, H Tang, Y Wu… - Cell Death & …, 2022 - nature.com
High-fat diet (HFD) has been implicated to promote colorectal cancer (CRC). Recently,
oncogene Cyclophilin B (CypB) is reported to be induced by cholesterol. However, the role …

Anti-obesity drug orlistat alleviates Western-diet-driven colitis-associated colon cancer via inhibition of STAT3 and NF-κB-mediated signaling

BR Jin, HJ Kim, SA Sim, M Lee, HJ An - Cells, 2021 - mdpi.com
Many researchers have argued that Western diet (WD)-induced obesity accelerates
inflammation and that inflammation is a link between obesity and colorectal cancer (CRC) …