NLRP3 inflammasome in cancer and metabolic diseases
BR Sharma, TD Kanneganti - Nature immunology, 2021 - nature.com
The NLRP3 inflammasome is a multimeric cytosolic protein complex that assembles in
response to cellular perturbations. This assembly leads to the activation of caspase-1, which …
response to cellular perturbations. This assembly leads to the activation of caspase-1, which …
Inflammasome signaling in colorectal cancer
BR Sharma, TD Kanneganti - Translational Research, 2023 - Elsevier
Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths in the world.
Inflammation is often an underlying risk factor for developing CRC. Maintaining gut …
Inflammation is often an underlying risk factor for developing CRC. Maintaining gut …
Blueberry and blackberry anthocyanins ameliorate metabolic syndrome by modulating gut microbiota and short-chain fatty acids metabolism in high-fat diet-fed C57BL …
L Du, H Lü, Y Chen, X Yu, T Jian, H Zhao… - Journal of Agricultural …, 2023 - ACS Publications
In this study, blueberry (Vaccinium ssp.) anthocyanins (VA) and blackberry (Rubus L.)
anthocyanins (RA) were used to investigate the effects on metabolic syndrome (MetS) and …
anthocyanins (RA) were used to investigate the effects on metabolic syndrome (MetS) and …
Wumei Pill Ameliorates AOM/DSS‐Induced Colitis‐Associated Colon Cancer through Inhibition of Inflammation and Oxidative Stress by Regulating S …
J Wang, K Ding, Y Wang, T Yan, Y Xu… - Oxidative Medicine …, 2022 - Wiley Online Library
Wumei Pill (WMP) is a traditional Chinese herbal formulation and widely used to treat
digestive system diseases in clinical. S‐Adenosylhomocysteine hydrolase (AHCY) can …
digestive system diseases in clinical. S‐Adenosylhomocysteine hydrolase (AHCY) can …
Theabrownin alleviates colorectal tumorigenesis in murine AOM/DSS model via PI3K/Akt/mTOR pathway suppression and gut microbiota modulation
Colorectal cancer (CRC) is one of the most common and fatal cancers worldwide, yet
therapeutic options for CRC often exhibit strong side effects which cause patients' well-being …
therapeutic options for CRC often exhibit strong side effects which cause patients' well-being …
Fusobacterium nucleatum Accelerates the Progression of Colitis-Associated Colorectal Cancer by Promoting EMT
MR Yu, HJ Kim, HR Park - Cancers, 2020 - mdpi.com
Simple Summary Colitis-associated cancer (CAC) are associated with the development and
progression of colorectal cancer (CRC). And Fusobacterium nucleatum (F. nucleatum), a …
progression of colorectal cancer (CRC). And Fusobacterium nucleatum (F. nucleatum), a …
Improving silymarin oral bioavailability using silica-installed redox nanoparticle to suppress inflammatory bowel disease
THT Nguyen, NT Trinh, HN Tran, HT Tran, PQ Le… - Journal of controlled …, 2021 - Elsevier
Chronic inflammatory diseases such as inflammatory bowel diseases (IBD), which are
strongly related to the overproduction of reactive oxygen species (ROS), have become more …
strongly related to the overproduction of reactive oxygen species (ROS), have become more …
Unveiling colitis: a journey through the dextran sodium sulfate-induced model
Animal models of inflammatory bowel disease (IBD) are valuable tools for investigating the
factors involved in IBD pathogenesis and evaluating new therapeutic options. The dextran …
factors involved in IBD pathogenesis and evaluating new therapeutic options. The dextran …
High-fat diet induced cyclophilin B enhances STAT3/lncRNA-PVT1 feedforward loop and promotes growth and metastasis in colorectal cancer
H Guo, K Zhuang, N Ding, R Hua, H Tang, Y Wu… - Cell Death & …, 2022 - nature.com
High-fat diet (HFD) has been implicated to promote colorectal cancer (CRC). Recently,
oncogene Cyclophilin B (CypB) is reported to be induced by cholesterol. However, the role …
oncogene Cyclophilin B (CypB) is reported to be induced by cholesterol. However, the role …
Anti-obesity drug orlistat alleviates Western-diet-driven colitis-associated colon cancer via inhibition of STAT3 and NF-κB-mediated signaling
BR Jin, HJ Kim, SA Sim, M Lee, HJ An - Cells, 2021 - mdpi.com
Many researchers have argued that Western diet (WD)-induced obesity accelerates
inflammation and that inflammation is a link between obesity and colorectal cancer (CRC) …
inflammation and that inflammation is a link between obesity and colorectal cancer (CRC) …