Following studies in the late 1990s that indicated that poor pharmacokinetics and toxicity
were important causes of costly late-stage failures in drug development, it has become …

Even in the 21st century, studies aimed at characterizing the pathological paradigms
associated with the development and progression of central nervous system diseases are …

A set of simple, consistent structure–property guides have been determined from an analysis
of a number of key ADMET assays run within GSK: solubility, permeability, bioavailability …

Computational (in silico) methods have been developed and widely applied to
pharmacology hypothesis development and testing. These in silico methods include …

The Golden Triangle is a visualization tool developed from in vitro permeability, in vitro
clearance and computational data designed to aid medicinal chemists in achieving …

Membrane transporters expressed by the hepatocyte and enterocyte play critical roles in
maintaining the enterohepatic circulation of bile acids, an effective recycling and …

Many of the drug candidates that fail in clinical trials are withdrawn because of unforeseen
effects of human metabolism, such as toxicity and unfavorable pharmacokinetic profiles …

Earning tenure at an academic institution and running a steeplechase race successfully
have a lot in common. Both require extensive training before the event begins, both involve …

Analysis of the literature involving computational modeling of diseases and drug design with
the aid of experimental spectroscopic techniques reveals that this specific combination of …

Efforts to improve oral drug bioavailability have grown in parallel with the pharmaceutical
industry. As the number and chemical diversity of drugs has increased, new strategies have …