The ability to detect stimuli from the environment plays a pivotal role in our survival. The
molecules that allow the detection of such signals include ion channels, which are proteins …

Phosphoinositides (PPIns) are lipid signaling molecules that act as master regulators of
cellular signaling. Recent studies have revealed novel roles of PPIns in myriad cellular …

INTRODUCTION Transient receptor potential melastatin member 8 (TRPM8) is a calcium-
permeable ion channel that serves as the principal detector of cold in humans. Natural and …

GABA A receptors are pentameric ligand-gated ion channels that mediate most fast
neuronal inhibition in the brain. In addition to their important physiological roles, they are …

Long-chain acyl-coenzyme A (LC-CoA) is a crucial metabolic intermediate that plays
important cellular regulatory roles, including activation and inhibition of ion channels. The …

The transient receptor potential melastatin 8 (TRPM8) ion channel is the primary detector of
environmental cold and an important target for treating pathological cold hypersensitivity …

Transient receptor potential vanilloid 2 (TRPV2) plays a critical role in neuronal
development, cardiac function, immunity, and cancer. Cannabidiol (CBD), the non …

Transient receptor potential (TRP) ion channels are sophisticated signaling machines that
detect a wide variety of environmental and physiological signals. Every cell in the body …

Transient receptor potential vanilloid 2 (TRPV2) is involved in many critical physiological
and pathophysiological processes, making it a promising drug target. Here we present cryo …

Lipids play important roles in regulating membrane protein function, but the molecular
mechanisms used are elusive. Here we investigated how anionic lipids modulate SthK, a …