The regulation and functions of DNA and RNA G-quadruplexes
DNA and RNA can adopt various secondary structures. Four-stranded G-quadruplex (G4)
structures form through self-recognition of guanines into stacked tetrads, and considerable …
structures form through self-recognition of guanines into stacked tetrads, and considerable …
DNA G-quadruplex structures: more than simple roadblocks to transcription?
J Robinson, F Raguseo, SP Nuccio… - Nucleic acids …, 2021 - academic.oup.com
It has been> 20 years since the formation of G-quadruplex (G4) secondary structures in
gene promoters was first linked to the regulation of gene expression. Since then, the …
gene promoters was first linked to the regulation of gene expression. Since then, the …
G4‐associated human diseases
N Maizels - EMBO reports, 2015 - embopress.org
Recent research has established clear connections between G‐quadruplexes and human
disease. Features of quadruplex structures that promote genomic instability have been …
disease. Features of quadruplex structures that promote genomic instability have been …
G-Quadruplex: a regulator of gene expression and its chemical targeting
Summary G-quadruplex (G4) is an important type of nucleic acid secondary structure. An
abundance of potential G4-forming sites have been shown to exist in genomes, leading to …
abundance of potential G4-forming sites have been shown to exist in genomes, leading to …
A Mechanosensor Mechanism Controls the G-Quadruplex/i-Motif Molecular Switch in the MYC Promoter NHE III1
MYC is overexpressed in many different cancer types and is an intensively studied
oncogene because of its contributions to tumorigenesis. The regulation of MYC is complex …
oncogene because of its contributions to tumorigenesis. The regulation of MYC is complex …
[HTML][HTML] Non-B DNA structures as a booster of genome instability
RC Duardo, F Guerra, S Pepe, G Capranico - Biochimie, 2023 - Elsevier
Non-canonical secondary structures (NCSs) are alternative nucleic acid structures that differ
from the canonical B-DNA conformation. NCSs often occur in repetitive DNA sequences and …
from the canonical B-DNA conformation. NCSs often occur in repetitive DNA sequences and …
Structure, properties, and biological relevance of the DNA and RNA G-quadruplexes: Overview 50 years after their discovery
NG Dolinnaya, AM Ogloblina, MG Yakubovskaya - Biochemistry (Moscow), 2016 - Springer
Abstract G-quadruplexes (G4s), which are known to have important roles in regulation of key
biological processes in both normal and pathological cells, are the most actively studied non …
biological processes in both normal and pathological cells, are the most actively studied non …
Stability and Kinetics of c-MYC Promoter G-Quadruplexes Studied by Single-Molecule Manipulation
A DNA G-quadruplex (G4) formed at the oncogene c-MYC promoter region functions as a
gene silencer. Due to its high stability at physiological K+ concentrations, its …
gene silencer. Due to its high stability at physiological K+ concentrations, its …
G-quadruplexes and associated proteins in aging and Alzheimer's disease
MJ Vijay Kumar, R Morales, AS Tsvetkov - Frontiers in Aging, 2023 - frontiersin.org
Aging is a prominent risk factor for many neurodegenerative disorders, such as Alzheimer's
disease (AD). Alzheimer's disease is characterized by progressive cognitive decline …
disease (AD). Alzheimer's disease is characterized by progressive cognitive decline …
DNA G-quadruplex structure participates in regulation of lipid metabolism through acyl-CoA binding protein
L Xiang, K Niu, Y Peng, X Zhang, X Li… - Nucleic Acids …, 2022 - academic.oup.com
Abstract G-quadruplex structure (G4) is a type of DNA secondary structure that widely exists
in the genomes of many organisms. G4s are believed to participate in multiple biological …
in the genomes of many organisms. G4s are believed to participate in multiple biological …