Phage-display immunoprecipitation sequencing of the antibody epitope repertoire in inflammatory bowel disease reveals distinct antibody signatures

AR Bourgonje, S Andreu-Sánchez, T Vogl, S Hu… - Immunity, 2023 - cell.com
Inflammatory bowel diseases (IBDs), eg, Crohn's disease (CD) and ulcerative colitis (UC),
are chronic immune-mediated inflammatory diseases. A comprehensive overview of an IBD …

Exploring immunome and microbiome interplay in reproductive health: current knowledge, challenges, and novel diagnostic tools

P Lingasamy, V Modhukur, R Mändar… - Seminars in …, 2024 - thieme-connect.com
The dynamic interplay between the immunome and microbiome in reproductive health is a
complex and rapidly advancing research field, holding tremendously vast possibilities for the …

[HTML][HTML] Phage immunoprecipitation and sequencing—a versatile technique for mapping the antibody reactome

GN Sundell, SC Tao - Molecular & Cellular Proteomics, 2024 - Elsevier
Characterizing the antibody reactome for circulating antibodies provide insight into
pathogen exposure, allergies and autoimmune diseases. This is important for biomarker …

Systemic antibody responses against gut microbiota flagellins implicate shared and divergent immune reactivity in Crohn's disease and chronic fatigue syndrome

AR Bourgonje, NV Hörstke, M Fehringer, G Innocenti… - Microbiome, 2024 - Springer
Background Elevated systemic antibody responses against gut microbiota flagellins are
observed in both Crohn's disease (CD) and myalgic encephalomyelitis/chronic fatigue …

[HTML][HTML] Untangling associations between immunoglobulin genotypes, repertoires and function

XC Dopico, M Mandolesi, GBK Hedestam - Immunology Letters, 2023 - Elsevier
Immunoglobulin (IG) genes, encoding B cell receptors (BCRs), are fundamental components
of the mammalian immune system, which evolved to recognize the diverse antigenic …

Maintenance of caecal homeostasis by diverse adaptive immune cells in the rhesus macaque

X Castro Dopico, M Guryleva… - Clinical & …, 2024 - Wiley Online Library
Objectives The caecum bridges the small and large intestine and plays a front‐line role in
discriminating gastrointestinal antigens. Although dysregulated in acute and chronic …

[HTML][HTML] Differential effects of heating modes on the immunogenic potential of soy-derived peptides released after in vitro infant digestion

J Tang, S Boeren, HJ Wichers, KA Hettinga - Food Research International, 2024 - Elsevier
During production of soy-based infant formula, soy protein undergoes heating processes.
This study investigated the differential impact of heating modes on the immunogenic …

Antibody signatures against viruses and microbiome reflect past and chronic exposures and associate with aging and inflammation

S Andreu-Sánchez, A Ripoll-Cladellas, A Culinscaia… - Iscience, 2024 - cell.com
Encounters with pathogens and other molecules can imprint long-lasting effects on our
immune system, influencing future physiological outcomes. Given the wide range of …

Linear epitopes of bony fish β-parvalbumins

E Franciskovic, L Thörnqvist, L Greiff, M Gasset… - Frontiers in …, 2024 - frontiersin.org
Introduction Fish β-parvalbumins are common targets of allergy-causing immunity. The
nature of antibody responses to such allergens determines the biological outcome following …

Phage Immunoprecipitation Sequencing (PhIP-Seq) for Analyzing Antibody Epitope Repertoires Against Food Antigens

I Filimonova, G Innocenti, T Vogl - Food Allergens: Methods and Protocols, 2023 - Springer
While thousands of food and environmental allergens have been reported, conventional
methods for allergy testing typically rely on measuring immunoglobulin E (IgE) binding …