Peptide-drug conjugates: a new hope for cancer management

VP Chavda, HK Solanki, M Davidson… - Molecules, 2022 - mdpi.com
Cancer remains the leading cause of death worldwide despite advances in treatment
options for patients. As such, safe and effective therapeutics are required. Short peptides …

The formulation of nanomedicines for treating tuberculosis

A Costa, M Pinheiro, J Magalhães, R Ribeiro… - Advanced drug delivery …, 2016 - Elsevier
Recent estimates indicate that tuberculosis (TB) is the leading cause of death worldwide,
alongside the human immunodeficiency virus (HIV) infection. The current treatment is …

Nanotechnology‐based targeted drug delivery: an emerging tool to overcome tuberculosis

Z Baranyai, H Soria‐Carrera, M Alleva… - Advanced …, 2021 - Wiley Online Library
The appearance and rapid spread of drug resistant strains of tuberculosis (TB), one of the
deadliest infectious diseases, pose a serious threat to public health and increase the need …

ConjuPepDB: a database of peptide–drug conjugates

B Balogh, M Ivánczi, B Nizami… - Nucleic Acids …, 2021 - academic.oup.com
Peptide–drug conjugates are organic molecules composed of (i) a small drug molecule,(ii) a
peptide and (iii) a linker. The drug molecule is mandatory for the biological action, however …

Novel Assay Platform to Evaluate Intracellular Killing of Mycobacterium tuberculosis: In Vitro and In Vivo Validation

K Horváti, K Fodor, B Pályi, J Henczkó, G Balka… - Frontiers in …, 2021 - frontiersin.org
One of the main hallmarks of tuberculosis (TB) is the ability of the causative agent to
transform into a stage of dormancy and the capability of long persistence in the host …

Size-dependent antimycobacterial activity of titanium oxide nanoparticles against Mycobacterium tuberculosis

V Ramalingam, S Sundaramahalingam… - Journal of Materials …, 2019 - pubs.rsc.org
Nanobiotechnology has offered new approaches for drug delivery and for the development
of medicines against microbial infections including the deadly multidrug-resistant …

Antimycobacterial activity of acetone extract and isolated metabolites from folklore medicinal lichen Usnea laevis Nyl. against drug-sensitive and multidrug-resistant …

VB Tatipamula, SSP Annam - Journal of Ethnopharmacology, 2022 - Elsevier
Abstract Ethnopharmacological relevance Tuberculosis (Tb) is one of the most infectious
diseases caused by Mycobacterium tuberculosis (Mt) with almost 2 million deaths yearly …

Spray-dried, nanoencapsulated, multi-drug anti-tuberculosis therapy aimed at once weekly administration for the duration of treatment

L Kalombo, Y Lemmer, B Semete-Makokotlela… - Nanomaterials, 2019 - mdpi.com
Aiming to improve the treatment outcomes of current daily tuberculosis (TB) chemotherapy
over several months, we investigated whether nanoencapsulation of existing drugs would …

Host cell targeting of novel antimycobacterial 4-aminosalicylic acid derivatives with tuftsin carrier peptides

LB Horváth, M Krátký, V Pflégr, E Méhes… - European Journal of …, 2022 - Elsevier
Mycobacterium tuberculosis is an intracellular pathogen and the uptake of the
antimycobacterial compounds by host cells is limited. Novel antimycobacterials effective …

Comparative analysis of internalisation, haemolytic, cytotoxic and antibacterial effect of membrane-active cationic peptides: Aspects of experimental setup

K Horváti, B Bacsa, T Mlinkó, N Szabó, F Hudecz… - Amino Acids, 2017 - Springer
Cationic peptides proved fundamental importance as pharmaceutical agents and/or drug
carrier moieties functioning in cellular processes. The comparison of the in vitro activity of …