The amino acid sequence of a protein affects both its structure and its function. Thus, the
ability to modify the sequence, and hence the structure and activity, of individual proteins in …

Solvent accessible surface area (SASA) of proteins has always been considered as a
decisive factor in protein folding and stability studies. It is defined as the surface …

Antibodies have become an indispensable tool for many biotechnological and clinical
applications. They bind their molecular target (antigen) by recognizing a portion of its …

The ability to predict local structural features of a protein from the primary sequence is of
paramount importance for unraveling its function in absence of experimental structural …

In eukaryotes, protein phosphorylation is specifically catalyzed by numerous protein kinases
(PKs), faithfully orchestrates various biological processes, and reversibly determines cellular …

The functional impact of the vast majority of cancer somatic mutations remains unknown,
representing a critical knowledge gap for implementing precision oncology. Here, we report …

Natural transformation is a broadly conserved mechanism of horizontal gene transfer in
bacterial species that can shape evolution and foster the spread of antibiotic resistance …

Alternative splicing (AS) generates vast transcriptomic and proteomic complexity. However,
which of the myriad of detected AS events provide important biological functions is not well …

SUMOylation is a reversible post-translational modification essential for genome stability.
Using high-resolution MS, we have studied global SUMOylation in human cells in a site …

It is critical for bacteria to recognize surface contact and initiate physiological changes
required for surface-associated lifestyles. Ubiquitous microbial appendages called pili are …