Zinc is a ubiquitous biological metal in all living organisms. The spatiotemporal zinc
dynamics in cells provide crucial cellular signaling opportunities, but also challenges for …

Manganese is an essential trace metal. The dysregulation of manganese seen in a broad
spectrum of neurological disorders reflects its importance in brain development and key …

Abstract Arginase, a manganese (Mn)-dependent enzyme, is indispensable for urea
generation and ammonia disposal in the liver. The potential role of fructose in Mn and …

Understanding of the immediate mechanisms of Mn-induced neurotoxicity is rapidly
evolving. We seek to provide a summary of recent findings in the field, with an emphasis to …

Manganese (Mn) is an essential trace element with unique functions in the body; it acts as a
cofactor for many enzymes involved in energy metabolism, the endogenous antioxidant …

Abstract Purpose of Review Exposure to environmental metals, like lead (Pb), manganese
(Mn), and methylmercury (Me-Hg), has consistently been implicated in neurodevelopmental …

Trace elements and metals play critical roles in the normal functioning of the central nervous
system (CNS), and their dysregulation has been implicated in neurodegenerative disorders …

Simple Summary The pollution of air, soil, and sea has grown in recent decades at the same
pace as human development. Climate changes add further damage to the ecosystems …

Introduction Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's
disease, Huntington's disease, amyotrophic lateral sclerosis and prion disease represent …

Manganese (Mn) is an essential trace element required for various biological processes.
However, excess Mn causes serious side effects in humans, including parkinsonism. Thus …