The etiology of central precocious puberty (CPP) is multiple and heterogeneous, including
congenital and acquired causes that can be associated with structural or functional brain …

Puberty marks the end of childhood and is a period when individuals undergo physiological
and psychological changes to achieve sexual maturation and fertility. The onset of puberty is …

Background: Prader-Willi syndrome (PWS) is a rare genetic disorder resulting from the lack
of expression of the PWS region (locus q11-q13) on the paternally derived chromosome 15 …

Central precocious puberty (CPP) is a condition in which the hypothalamus–pituitary–
gonadal system is activated earlier than the normal developmental stage. The etiology …

The hypothalamus regulates fundamental aspects of physiological homeostasis and
behavior, including stress response, reproduction, growth, sleep, and feeding, several of …

Despite the growing prevalence of central precocious puberty (CPP), most cases are still
diagnosed as “idiopathic” due to the lack of identifiable findings of other diagnostic etiology …

Objectives Central precocious puberty (CPP) develops as a result of early stimulation of the
hypothalamic-pituitary-gonadal (HPG) axis. The loss-of-function mutations in the Makorin …

The initiation of puberty is a crucial timepoint of development, with its disruptions being
associated with multiple physical and psychological complications. Idiopathic Central …

Genetic syndromes that affect the nervous system may also disrupt testicular function, and
the mechanisms for these effects may be interrelated. Most often neurological signs and …

Diagnosis and management of precocious puberty are challenging. The two main classes of
precocious puberty are Central Precocious Puberty (CPP) and Peripheral Precocious …