For many years, transcription factor Sp1 was viewed as a basal transcription factor and
relegated to a role in the regulation of so‐called housekeeping genes. Identification of Sp1's …

The incidence of many types of cancer arising in organs with non-reproductive functions is
significantly higher in male populations than in female populations, with associated …

Historically women were frequently excluded from clinical trials and drug usage to protect
unborn babies from potential harm. As a consequence, the impact of sex and gender on …

High Gleason grade prostate carcinomas are aggressive, poorly differentiated tumors that
exhibit diminished estrogen receptor β (ERβ) expression. We report that a key function of …

Sp1 belongs to the 26 member strong Sp/KLF family of transcription factors. It is a paradigm
for a ubiquitously expressed transcription factor and is involved in regulating the expression …

Specificity protein 1 (Sp1) and other Sp and Krüppel-like factor (KLF) proteins are members
of a family of transcription factors which bind GC/GT-rich promoter elements through three …

The vascular endothelial growth factor A (VEGF-A) is essential during embryonic
development as inactivation of only one allele of its gene results in embryonic lethality. Up …

Abstract 17β-Estradiol (E2) binds to the estrogen receptor (ER) to activate gene expression
or repression and this involves both genomic (nuclear) and non-genomic (extranuclear …

La famille de facteurs de transcription Sp partage une combinaison particulière de trois
motifs à doigts de zinc Cys2His2 qui forment le domaine spécifique de liaison à l'ADN. Au …

Estrogen stimulates the proliferation of the most common type of human breast cancer that
expresses estrogen receptor α (ERα) through the activation of the cyclin D1 (CCND1) …