Highlights•Sex development depends on spatio-temporal sequence & coordination of
mutually antagonistic activating & repressing factors.•Disorders of sex development can be …

Sex-specific gonadal development starts with formation of the bipotential gonad, which then
differentiates into either a mature testis or an ovary. This process is dependent on activation …

It is paramount that any child or adolescent with a suspected disorder of sex development
(DSD) is assessed by an experienced clinician with adequate knowledge about the range of …

Formerly known as' intersex'conditions, disorders of sex development (DSDs) are congenital
conditions in which chromosomal, gonadal or anatomical sex is atypical. A complete …

Fetal sex development consists of three sequential stages: a) the undifferentiated stage,
when identical primitive structures develop in the XY and XX embryos, b) gonadal …

Disorders of sexual development (DSD) are conditions with an atypical chromosomal,
gonadal or phenotypic sex, which leads to differences in the development of the urogenital …

Background: Prenatal deficit of androgens or androgen action results in atypical genitalia in
individuals with XY disorders of sex development (XY, DSD). XY, DSD include mainly …

Sequential hermaphroditism is a unique reproductive strategy among teleosts that is
displayed mainly in fish species living in the coral reef environment. The reproductive …

It is paramount that any child or adolescent with a suspected disorder of sex development
(DSD) is assessed by an experienced clinician with adequate knowledge about the range of …

Background SOX9 mutations cause the skeletal malformation syndrome campomelic
dysplasia in combination with XY sex reversal. Studies in mice indicate that SOX9 acts as a …