Disorders of sex development
SF Witchel - Best Practice & Research Clinical Obstetrics & …, 2018 - Elsevier
Highlights•Sex development depends on spatio-temporal sequence & coordination of
mutually antagonistic activating & repressing factors.•Disorders of sex development can be …
mutually antagonistic activating & repressing factors.•Disorders of sex development can be …
Genetic regulation of mammalian gonad development
S Eggers, T Ohnesorg, A Sinclair - Nature Reviews Endocrinology, 2014 - nature.com
Sex-specific gonadal development starts with formation of the bipotential gonad, which then
differentiates into either a mature testis or an ovary. This process is dependent on activation …
differentiates into either a mature testis or an ovary. This process is dependent on activation …
Society for Endocrinology UK guidance on the initial evaluation of an infant or an adolescent with a suspected disorder of sex development (Revised 2015)
It is paramount that any child or adolescent with a suspected disorder of sex development
(DSD) is assessed by an experienced clinician with adequate knowledge about the range of …
(DSD) is assessed by an experienced clinician with adequate knowledge about the range of …
Disorders of sex development: new genes, new concepts
M Ono, VR Harley - Nature Reviews Endocrinology, 2013 - nature.com
Formerly known as' intersex'conditions, disorders of sex development (DSDs) are congenital
conditions in which chromosomal, gonadal or anatomical sex is atypical. A complete …
conditions in which chromosomal, gonadal or anatomical sex is atypical. A complete …
Normal male sexual differentiation and aetiology of disorders of sex development
RA Rey, RP Grinspon - Best Practice & Research Clinical Endocrinology & …, 2011 - Elsevier
Fetal sex development consists of three sequential stages: a) the undifferentiated stage,
when identical primitive structures develop in the XY and XX embryos, b) gonadal …
when identical primitive structures develop in the XY and XX embryos, b) gonadal …
Disorders of sexual development: current status and progress in the diagnostic approach
M García-Acero, O Moreno, F Suárez, A Rojas - Current urology, 2020 - karger.com
Disorders of sexual development (DSD) are conditions with an atypical chromosomal,
gonadal or phenotypic sex, which leads to differences in the development of the urogenital …
gonadal or phenotypic sex, which leads to differences in the development of the urogenital …
Satisfaction with genital surgery and sexual life of adults with XY disorders of sex development: results from the German clinical evaluation study
B Köhler, E Kleinemeier, A Lux, O Hiort… - The Journal of …, 2012 - academic.oup.com
Background: Prenatal deficit of androgens or androgen action results in atypical genitalia in
individuals with XY disorders of sex development (XY, DSD). XY, DSD include mainly …
individuals with XY disorders of sex development (XY, DSD). XY, DSD include mainly …
Sex change in clownfish: molecular insights from transcriptome analysis
Sequential hermaphroditism is a unique reproductive strategy among teleosts that is
displayed mainly in fish species living in the coral reef environment. The reproductive …
displayed mainly in fish species living in the coral reef environment. The reproductive …
UK guidance on the initial evaluation of an infant or an adolescent with a suspected disorder of sex development
It is paramount that any child or adolescent with a suspected disorder of sex development
(DSD) is assessed by an experienced clinician with adequate knowledge about the range of …
(DSD) is assessed by an experienced clinician with adequate knowledge about the range of …
Copy number variation of two separate regulatory regions upstream of SOX9 causes isolated 46, XY or 46, XX disorder of sex development
GJ Kim, E Sock, A Buchberger, W Just… - Journal of Medical …, 2015 - jmg.bmj.com
Background SOX9 mutations cause the skeletal malformation syndrome campomelic
dysplasia in combination with XY sex reversal. Studies in mice indicate that SOX9 acts as a …
dysplasia in combination with XY sex reversal. Studies in mice indicate that SOX9 acts as a …