Lipid metabolism and Alzheimer's disease: clinical evidence, mechanistic link and therapeutic promise
F Yin - The FEBS journal, 2023 - Wiley Online Library
Alzheimer's disease (AD) is an age‐associated neurodegenerative disorder with
multifactorial etiology, intersecting genetic and environmental risk factors, and a lack of …
multifactorial etiology, intersecting genetic and environmental risk factors, and a lack of …
Lipids and Alzheimer's disease
YC Kao, PC Ho, YK Tu, IM Jou, KJ Tsai - International journal of molecular …, 2020 - mdpi.com
Lipids, as the basic component of cell membranes, play an important role in human health
as well as brain function. The brain is highly enriched in lipids, and disruption of lipid …
as well as brain function. The brain is highly enriched in lipids, and disruption of lipid …
Involvement of lipids in Alzheimer's disease pathology and potential therapies
H Chew, VA Solomon, AN Fonteh - Frontiers in physiology, 2020 - frontiersin.org
Lipids constitute the bulk of the dry mass of the brain and have been associated with healthy
function as well as the most common pathological conditions of the brain. Demographic …
function as well as the most common pathological conditions of the brain. Demographic …
The cell biology of the retinal pigment epithelium
A Lakkaraju, A Umapathy, LX Tan, L Daniele… - Progress in retinal and …, 2020 - Elsevier
The retinal pigment epithelium (RPE), a monolayer of post-mitotic polarized epithelial cells,
strategically situated between the photoreceptors and the choroid, is the primary caretaker of …
strategically situated between the photoreceptors and the choroid, is the primary caretaker of …
[HTML][HTML] Circulating microRNAs as potential biomarkers for psychiatric and neurodegenerative disorders
MMJ Van den Berg, J Krauskopf, JG Ramaekers… - Progress in …, 2020 - Elsevier
Circulating microRNAs (cimiRNAs) are a class of non-encoding RNAs found in bodily fluids
such as blood, cerebrospinal fluid (CSF) and tears. CimiRNAs have been implicated as …
such as blood, cerebrospinal fluid (CSF) and tears. CimiRNAs have been implicated as …
Lipid metabolism and storage in neuroglia: role in brain development and neurodegenerative diseases
D Yang, X Wang, L Zhang, Y Fang, Q Zheng, X Liu… - Cell & Bioscience, 2022 - Springer
The importance of neuroglia in maintaining normal brain function under physiological and
pathological conditions has been supported by growing evidence in recent years. The most …
pathological conditions has been supported by growing evidence in recent years. The most …
Sphingolipids: membrane microdomains in brain development, function and neurological diseases
ASB Olsen, NJ Færgeman - Open biology, 2017 - royalsocietypublishing.org
Sphingolipids are highly enriched in the nervous system where they are pivotal constituents
of the plasma membranes and are important for proper brain development and functions …
of the plasma membranes and are important for proper brain development and functions …
Repairing mitochondrial dysfunction in disease
V Sorrentino, KJ Menzies… - Annual review of …, 2018 - annualreviews.org
Mitochondria are essential organelles for many aspects of cellular homeostasis, including
energy harvesting through oxidative phosphorylation. Alterations of mitochondrial function …
energy harvesting through oxidative phosphorylation. Alterations of mitochondrial function …
Increased localization of APP‐C99 in mitochondria‐associated ER membranes causes mitochondrial dysfunction in Alzheimer disease
M Pera, D Larrea, C Guardia‐Laguarta… - The EMBO …, 2017 - embopress.org
In the amyloidogenic pathway associated with Alzheimer disease (AD), the amyloid
precursor protein (APP) is cleaved by β‐secretase to generate a 99‐aa C‐terminal fragment …
precursor protein (APP) is cleaved by β‐secretase to generate a 99‐aa C‐terminal fragment …
Ceramides as novel disease biomarkers
J Kurz, MJ Parnham, G Geisslinger… - Trends in molecular …, 2019 - cell.com
Ceramides are sphingolipids and integral components of the eukaryotic cell membrane.
Apart from providing structural integrity, ceramides have also been shown to act as second …
Apart from providing structural integrity, ceramides have also been shown to act as second …