Metalloproteinases and their roles in human cancer
It is now widely appreciated that members of the matrix metalloproteinase (MMP) family of
enzymes play a key role in cancer development and progression along with many of the …
enzymes play a key role in cancer development and progression along with many of the …
ADAMTS‐5: A difficult teenager turning 20
S Santamaria - International journal of experimental pathology, 2020 - Wiley Online Library
Summary A Disintegrin And Metalloproteinase with ThromboSpondin motif (ADAMTS)‐5
was identified in 1999 as one of the enzymes responsible for cleaving aggrecan, the major …
was identified in 1999 as one of the enzymes responsible for cleaving aggrecan, the major …
Emerging roles of redox‐mediated angiogenesis and oxidative stress in dermatoses
D Xian, J Song, L Yang, X Xiong, R Lai… - … medicine and cellular …, 2019 - Wiley Online Library
Angiogenesis is the process of new vessel formation, which sprouts from preexisting
vessels. This process is highly complex and primarily involves several key steps, including …
vessels. This process is highly complex and primarily involves several key steps, including …
Mitochondrial aldehyde dehydrogenase 2 represents a potential biomarker of biochemical recurrence in prostate cancer patients
D Feng, W Zhu, J You, X Shi, P Han, W Wei, Q Wei… - Molecules, 2022 - mdpi.com
Background: We aimed to explore the role of mitochondrial aldehyde dehydrogenase 2
(ALDH2) in prostate cancer (PCa) patients and provide insights into the tumor immune …
(ALDH2) in prostate cancer (PCa) patients and provide insights into the tumor immune …
Metalloprotease ADAMTS-1 decreases cell migration and invasion modulating the spatiotemporal dynamics of Cdc42 activity
M de Assis Lima, SV da Silva, O Serrano-Garrido… - Cellular signalling, 2021 - Elsevier
Abstract ADAMTSs (AD isintegrin And Metalloproteinase with ThromboSpondin motifs) are
secreted proteases dependent on Zn 2+/Ca 2+, involved in physiological and pathological …
secreted proteases dependent on Zn 2+/Ca 2+, involved in physiological and pathological …
Identification of subtype-specific metastasis-related genetic signatures in sarcoma
YL Li, YL Gao, XL Niu, YT Wu, YM Du, MS Tang… - Frontiers in …, 2020 - frontiersin.org
Background: Sarcomas are heterogeneous rare malignancies constituting approximately
1% of all solid cancers in adults and including more than 70 histological and molecular …
1% of all solid cancers in adults and including more than 70 histological and molecular …
Increased Expression and Prognostic Significance of BYSL in Melanoma
Z Wang, G Yao, L Wang, Y Zhu… - Journal of …, 2024 - journals.lww.com
We evaluated the BYSL content and underlying mechanism in melanoma (SKCM) overall
survival (OS). In this study, we used a comprehensive approach combining bioinformatics …
survival (OS). In this study, we used a comprehensive approach combining bioinformatics …
In silico identification of contradictory role of ADAMTS5 in hepatocellular carcinoma
Z Zhu, J Xu, X Wu, S Lin, L Li, W Ye… - Technology in Cancer …, 2021 - journals.sagepub.com
Background: ADAMTS5 has different roles in multiple types of cancers and participates in
various molecular mechanisms. However, the prognostic value of ADAMTS5 in patients with …
various molecular mechanisms. However, the prognostic value of ADAMTS5 in patients with …
Cell surface nucleolin is a novel ADAMTS5 receptor mediating endothelial cell apoptosis
DC Kirman, B Renganathan, WK Chui, MW Chen… - Cell Death & …, 2022 - nature.com
A Disintegrin and Metalloproteinase with ThromboSpondin motif (ADAMTS) 5 functions as
an anti-angiogenic and anti-cancer protein independent of its metalloproteinase activity …
an anti-angiogenic and anti-cancer protein independent of its metalloproteinase activity …