Platelets are the smallest blood cells, numbering 150 to 350× 10 9/L in healthy individuals.
The ability of activated platelets to adhere to an injured vessel wall and form aggregates was …

Platelets are abundant, small, anucleate circulating cells, serving many emerging
pathophysiological roles beyond hemostasis; including active critical roles in thrombosis …

Platelet granules are unique among secretory vesicles in both their content and their life
cycle. Platelets contain three major granule types—dense granules, α-granules, and …

Platelets contain a vast number of biologically active molecules within cytoplasmic granules
which are classified according to their respective distinct ultrastructures, densities and …

Platelets are critical to hemostatic and immunological function, and are key players in cancer
progression, metastasis, and cancer-related thrombosis. Platelets interact with immune cells …

Platelets are the smallest of the many types of cells in circulating blood, averaging only 2.0
to 5.0 μm in diameter, 0.5 μm in thickness, and having a mean cell volume of 6 to 10 …

The energy-dependent release of granule contents from activated platelets is a well-
established component of normal hemostasis and thrombosis. A role for membrane fusion in …

Vascular endothelial growth factor (VEGF) is a secreted endothelial cell-specific mitogen
and permeability factor. Malignant human tumors have been shown to produce VEGF …

Background Platelets (PLT s) in stored PLT concentrates (PLC s) release PLT extracellular
vesicles (PL‐EV s) induced by senescence and activation, resembling the PLT storage …

Stimulation of platelets with strong agonists results in centralization of cytoplasmic
organelles and secretion of granules. These observations have led to the supposition that …