The metabolite acetyl-CoA is necessary for both lipid synthesis in the cytosol and histone
acetylation in the nucleus. The two canonical precursors to acetyl-CoA in the nuclear …

Anaerobic methanotrophic (ANME) archaea are environmentally important, uncultivated
microorganisms that oxidize the potent greenhouse gas methane. During methane …

Dengue human infection models present an opportunity to explore the potential of a vaccine,
anti-viral or immuno-compound for clinical benefit in a controlled setting. Here we report the …

The molecular mechanisms that regulate breast cancer cell (BCC) metastasis and
proliferation within the leptomeninges (LM) are poorly understood, which limits the …

Acinar cells are the principal secretory units of multiple exocrine organs. A single-cell,
layered, lumenized acinus forms from a large cohort of epithelial progenitors that must …

Semen quality and fertility has declined over the last 50 years, corresponding to ever-
increasing environmental stressors. However, the cellular mechanisms involved and their …

Initial TCR engagement (priming) of naive CD8+ T cells results in T cell expansion, and
these early events influence the generation of diverse effector and memory populations …

A promising candidate for arbovirus control and prevention relies on replacing arbovirus-
susceptible Aedes aegypti populations with mosquitoes that have been colonized by the …

Salivary gland dysfunction worsens the quality of life, but treatment for restoration of salivary
gland function is limited. Although previous reports have demonstrated the therapeutic …

Among the first microorganisms to colonize the human gut of breastfed infants are bacteria
capable of fermenting human milk oligosaccharides (HMOs). One of the most abundant …