Forty years of clathrin‐coated vesicles
MS Robinson - Traffic, 2015 - Wiley Online Library
The purification of coated vesicles and the discovery of clathrin by Barbara Pearse in 1975
was a landmark in cell biology. Over the past 40 years, work from many labs has uncovered …
was a landmark in cell biology. Over the past 40 years, work from many labs has uncovered …
The retromer complex–endosomal protein recycling and beyond
MNJ Seaman - Journal of cell science, 2012 - journals.biologists.com
The retromer complex is a vital element of the endosomal protein sorting machinery that is
conserved across all eukaryotes. Retromer is most closely associated with the endosome-to …
conserved across all eukaryotes. Retromer is most closely associated with the endosome-to …
New insights into the genetic etiology of Alzheimer's disease and related dementias
Abstract Characterization of the genetic landscape of Alzheimer's disease (AD) and related
dementias (ADD) provides a unique opportunity for a better understanding of the associated …
dementias (ADD) provides a unique opportunity for a better understanding of the associated …
[HTML][HTML] Sorting of lysosomal proteins
T Braulke, JS Bonifacino - Biochimica et Biophysica Acta (BBA)-Molecular …, 2009 - Elsevier
Lysosomes are composed of soluble and transmembrane proteins that are targeted to
lysosomes in a signal-dependent manner. The majority of soluble acid hydrolases are …
lysosomes in a signal-dependent manner. The majority of soluble acid hydrolases are …
[HTML][HTML] VPS35 deficiency or mutation causes dopaminergic neuronal loss by impairing mitochondrial fusion and function
Summary Vacuolar protein sorting-35 (VPS35) is a retromer component for endosomal
trafficking. Mutations of VPS35 have been linked to familial Parkinson's disease (PD). Here …
trafficking. Mutations of VPS35 have been linked to familial Parkinson's disease (PD). Here …
Depletion of the AD risk gene SORL1 selectively impairs neuronal endosomal traffic independent of amyloidogenic APP processing
A Knupp, S Mishra, R Martinez, JE Braggin, M Szabo… - Cell reports, 2020 - cell.com
SORL1/SORLA is a sorting receptor involved in retromer-related endosomal traffic and an
Alzheimer's disease (AD) risk gene. Using CRISPR-Cas9, we deplete SORL1 in hiPSCs to …
Alzheimer's disease (AD) risk gene. Using CRISPR-Cas9, we deplete SORL1 in hiPSCs to …
Linking Aβ and tau in late-onset Alzheimer's disease: a dual pathway hypothesis
Alzheimer's disease is characterized by abnormal elevation of Aβ peptide and abnormal
hyperphosphorylation of the tau protein. The" amyloid hypothesis," which is based on …
hyperphosphorylation of the tau protein. The" amyloid hypothesis," which is based on …
GDNF synthesis, signaling, and retrograde transport in motor neurons
AF Cintrón-Colón, G Almeida-Alves, AM Boynton… - Cell and tissue …, 2020 - Springer
Glial cell line–derived neurotrophic factor (GDNF) is a 134 amino acid protein belonging in
the GDNF family ligands (GFLs). GDNF was originally isolated from rat glial cell lines and …
the GDNF family ligands (GFLs). GDNF was originally isolated from rat glial cell lines and …
Sorting nexins provide diversity for retromer-dependent trafficking events
PJ Cullen, HC Korswagen - Nature cell biology, 2012 - nature.com
Sorting nexins are a large family of evolutionarily conserved phosphoinositide-binding
proteins that have fundamental roles in orchestrating cargo sorting through the membranous …
proteins that have fundamental roles in orchestrating cargo sorting through the membranous …
Insights into the PX (phox-homology) domain and SNX (sorting nexin) protein families: structures, functions and roles in disease
RD Teasdale, BM Collins - Biochemical Journal, 2012 - portlandpress.com
The mammalian genome encodes 49 proteins that possess a PX (phox-homology) domain,
responsible for membrane attachment to organelles of the secretory and endocytic system …
responsible for membrane attachment to organelles of the secretory and endocytic system …