[HTML][HTML] An updated review on synthetic cathinones

J Soares, VM Costa, ML Bastos, F Carvalho… - Archives of …, 2021 - Springer
Cathinone, the main psychoactive compound found in the plant Catha edulis Forsk.(khat), is
a β-keto analogue of amphetamine, sharing not only the phenethylamine structure, but also …

Structure–Activity Relationship of Synthetic Cathinones: An Updated Review

N Nadal-Gratacós, MD Pazos, D Pubill… - ACS Pharmacology & …, 2024 - ACS Publications
The escalating prevalence of new psychoactive substances (NPSs) poses a significant
public health challenge, evidenced by the vast chemical diversity, with over 500 substances …

Synthetic cathinones induce cell death in dopaminergic SH-SY5Y cells via stimulating mitochondrial dysfunction

HS Leong, M Philp, M Simone, PK Witting… - International journal of …, 2020 - mdpi.com
Increasing reports of neurological and psychiatric complications due to psychostimulant
synthetic cathinones (SCs) have recently raised public concern. However, the precise …

Novel psychoactive substances: the razor's edge between therapeutical potential and psychoactive recreational misuse

B Correia, J Fernandes, MJ Botica, C Ferreira… - Medicines, 2022 - mdpi.com
Background: Novel psychoactive substances (NPS) are compounds of natural and synthetic
origin, similar to traditional drugs of abuse. NPS are involved in a contemporary trend whose …

Determination of selected cathinones in blood by solid-phase extraction and GC–MS

M Antunes, M Sequeira… - Journal of Analytical …, 2021 - academic.oup.com
The emergence of potentially dangerous new psychoactive substances (NPS) is challenging
for forensic laboratories, as well as the ability to develop and validate methods for a rapid …

Quantitative spectrofluorometric assay detecting nuclear condensation and fragmentation in intact cells

P Majtnerova, J Capek, F Petira, J Handl, T Rousar - Scientific reports, 2021 - nature.com
At present, nuclear condensation and fragmentation have been estimated also using
Hoechst probes in fluorescence microscopy and flow cytometry. However, none of the …

Semi-Preparative Separation, Absolute Configuration, Stereochemical Stability and Effects on Human Neuronal Cells of MDPV Enantiomers

AS Almeida, B Silva, JP Silva, JA Pereira, F Remião… - Molecules, 2023 - mdpi.com
Synthetic cathinones, such as 3, 4-methylenedioxypyrovalerone (MDPV), are widely abused
due to their psychostimulant effects. As they are chiral molecules, studies of their …

Four synthetic cathinones: 3-chloromethcathinone, 4-chloromethcathinone, 4-fluoro-α-pyrrolidinopentiophenone, and 4-methoxy-α-pyrrolidinopentiophenone produce …

J Wojcieszak, K Kuczyńska, JB Zawilska - Neurotoxicity Research, 2020 - Springer
Abstract Two chloromethcathinones, 3-chloromethcathinone (3-CMC) and 4-
chloromethcathinone (4-CMC), and two para-substituted α-pyrrolidinophenones, 4-methoxy …

4-Isobutylmethcathinone—A Novel Synthetic Cathinone with High In Vitro Cytotoxicity and Strong Receptor Binding Preference of Enantiomers

M Paškan, S Rimpelová, V Svobodová Pavlíčková… - Pharmaceuticals, 2022 - mdpi.com
New psychoactive substances and among them synthetic cathinones represent a significant
threat to human health globally. However, within such a large pool of substances derived …

[HTML][HTML] Synthesis of emerging cathinones and validation of a SPE GC–MS method for their simultaneous quantification in blood

S Júlio, RA Ferro, S Santos, A Alexandre… - Analytical and …, 2023 - Springer
Over the past 15 years, synthetic cathinones have emerged as an important class of new
psychoactive substances (NPS) worldwide. The proliferation of these psychostimulants and …