Recovery from disorders of consciousness: mechanisms, prognosis and emerging therapies

BL Edlow, J Claassen, ND Schiff… - Nature Reviews Neurology, 2021 - nature.com
Substantial progress has been made over the past two decades in detecting, predicting and
promoting recovery of consciousness in patients with disorders of consciousness (DoC) …

Clinical and advanced neurophysiology in the prognostic and diagnostic evaluation of disorders of consciousness: review of an IFCN-endorsed expert group

A Comanducci, M Boly, J Claassen, M De Lucia… - Clinical …, 2020 - Elsevier
The analysis of spontaneous EEG activity and evoked potentials is a cornerstone of the
instrumental evaluation of patients with disorders of consciousness (DoC). The past few …

Prognostication after cardiac arrest

C Sandroni, S D'Arrigo, JP Nolan - Critical care, 2018 - Springer
Hypoxic–ischaemic brain injury (HIBI) is the main cause of death in patients who are
comatose after resuscitation from cardiac arrest. A poor neurological outcome—defined as …

[HTML][HTML] Complementary roles of neural synchrony and complexity for indexing consciousness and chances of surviving in acute coma

SL Alnes, M De Lucia, AO Rossetti, A Tzovara - NeuroImage, 2021 - Elsevier
An open challenge in consciousness research is understanding how neural functions are
altered by pathological loss of consciousness. To maintain consciousness, the brain needs …

Deep learning for EEG-based prognostication after cardiac arrest: from current research to future clinical applications

F Zubler, A Tzovara - Frontiers in neurology, 2023 - frontiersin.org
Outcome prognostication in comatose patients after cardiac arrest (CA) remains to date a
challenge. The major determinant of clinical outcome is the post-hypoxic/ischemic …

Estimating the false positive rate of absent somatosensory evoked potentials in cardiac arrest prognostication

E Amorim, MM Ghassemi, JW Lee, DM Greer… - Critical care …, 2018 - journals.lww.com
Objectives: Absence of somatosensory evoked potentials is considered a nearly perfect
predictor of poor outcome after cardiac arrest. However, reports of good outcomes despite …

[HTML][HTML] Quantitative analysis of early-stage EEG reactivity predicts awakening and recovery of consciousness in patients with severe brain injury

E Bouchereau, A Marchi, B Hermann… - British Journal of …, 2023 - Elsevier
Background Decisions of withdrawal of life-sustaining therapy for patients with severe brain
injury are often based on prognostic evaluations such as analysis of …

NeuroTec sitem-insel bern: closing the last mile in neurology

KA Schindler, T Nef, MO Baud, A Tzovara… - Clinical and …, 2021 - mdpi.com
Neurology is focused on a model where patients receive their care through repeated visits to
clinics and doctor's offices. Diagnostic tests often require expensive and specialized …

Automatic sensory predictions: a review of predictive mechanisms in the brain and their link to conscious processing

RI Tivadar, RT Knight, A Tzovara - Frontiers in human neuroscience, 2021 - frontiersin.org
The human brain has the astonishing capacity of integrating streams of sensory information
from the environment and forming predictions about future events in an automatic way …

Brain-computer interfaces for consciousness assessment and communication in severely brain-injured patients

J Annen, S Laureys, O Gosseries - Handbook of clinical neurology, 2020 - Elsevier
Patients with disorders of consciousness (DOC) suffer from awareness deficits.
Comorbidities such as motor disabilities or visual problems hamper clinical assessments …