Coenzyme Q10 in atherosclerosis

M Liao, X He, Y Zhou, W Peng, XM Zhao… - European Journal of …, 2024 - Elsevier
Atherosclerotic disease is a chronic disease that predominantly affects the elderly and is the
most common cause of cardiovascular death worldwide. Atherosclerosis is closely related to …

Cancer cell stiffening via CoQ10 and UBIAD1 regulates ECM signaling and ferroptosis in breast cancer

G Tosi, A Paoli, G Zuccolotto, E Turco… - Nature …, 2024 - nature.com
Abstract CoQ10 (Coenzyme Q10) is an essential fat-soluble metabolite that plays a key role
in cellular metabolism. A less-known function of CoQ10 is whether it may act as a plasma …

SARS-CoV-2 RBD and its variants can induce platelet activation and clearance: Implications for antibody therapy and vaccinations against COVID-19

X Ma, J Liang, G Zhu, P Bhoria, AA Shoara… - Research, 2023 - spj.science.org
The COVID-19 pandemic caused by SARS-CoV-2 virus is an ongoing global health burden.
Severe cases of COVID-19 and the rare cases of COVID-19 vaccine-induced-thrombotic …

Protocatechuic acid protects platelets from apoptosis via inhibiting oxidative stress-mediated PI3K/Akt/GSK3β signaling

F Ya, K Li, H Chen, Z Tian, Y Shi, F Song… - Thrombosis and …, 2021 - thieme-connect.com
Oxidative stress plays crucial roles in initiating platelet apoptosis that facilitates the
progression of cardiovascular diseases (CVDs). Protocatechuic acid (PCA), a major …

Coenzyme Q10 attenuates human platelet aggregation induced by SARS-CoV-2 spike protein via reducing oxidative stress in vitro

R Wang, Y Chen, Z Tian, M Zhu, B Zhang, S Du… - International Journal of …, 2022 - mdpi.com
Platelet hyperreactivity and oxidative stress are the important causes of thrombotic disorders
in patients with COVID-19. Oxidative stress, induced by the excessive generation of reactive …

A fingerprint of plasma proteome alteration after local tissue damage induced by Bothrops leucurus snake venom in mice

J dos Santos Cavalcante, CAS de Almeida… - Journal of …, 2022 - Elsevier
Bothrops spp. is responsible for about 70% of snakebites in Brazil, causing a diverse and
complex pathophysiological condition. Bothrops leucurus is the main species of medical …

Cyanidin-3-O-β-Glucoside Attenuates Platelet Chemokines and Their Receptors in Atherosclerotic Inflammation of ApoE–/– Mice

Y Yao, X Zhang, Y Xu, Y Zhao, F Song… - Journal of Agricultural …, 2022 - ACS Publications
Platelet chemokines play well-established roles in the atherosclerotic inflammation.
Cyanidin-3-O-β-glucoside (Cy-3-g) is one of the main bioactive compounds in anthocyanins …

Therapeutic Effects of Coenzyme Q10 in the Treatment of Ischemic Stroke

Z Jia, X Yu, X Wang, J Li - Current Nutrition Reports, 2024 - Springer
Abstract Purpose of Review Ischemic stroke is the second deadly disease worldwide, but
current treatment is very limited. The brain, rich in lipids and high in oxygen consumption, is …

Ginsenosides Rb2 and Rd2 isolated from Panax notoginseng flowers attenuate platelet function through P2Y 12-mediated cAMP/PKA and PI3K/Akt/Erk1/2 signaling

X Zuo, Q Li, F Ya, LJ Ma, Z Tian, M Zhao, D Fan… - Food & Function, 2021 - pubs.rsc.org
Saponins derived from Panax notoginseng root are widely used as herbal medicines and
dietary supplements due to their wide range of health benefits. However, the effects of those …

Tetrahydrocurcumin downregulates MAPKs/cPLA2 signaling and attenuates platelet thromboxane A2 generation, granule secretion, and thrombus growth

W Li, Y Ma, C Zhang, B Chen, X Zhang… - Thrombosis and …, 2022 - thieme-connect.com
Platelet granule secretion plays a key role in atherothrombosis. Curcumin, a natural
polyphenol compound derived from turmeric, exerts multiple biological activities. The current …