Radiotherapy toxicity

D De Ruysscher, G Niedermann, NG Burnet… - Nature Reviews …, 2019 - nature.com
Radiotherapy is used in> 50% of patients with cancer, both for curative and palliative
purposes. Radiotherapy uses ionizing radiation to target and kill tumour tissue, but normal …

Normal tissue complication probability (NTCP) models for modern radiation therapy

G Palma, S Monti, M Conson, R Pacelli, L Cella - Seminars in oncology, 2019 - Elsevier
Mathematical models of normal tissue complication probability (NTCP) able to robustly
predict radiation-induced morbidities (RIM) play an essential role in the identification of a …

[HTML][HTML] Regional responses in radiation-induced normal tissue damage

DC Voshart, J Wiedemann, P van Luijk, L Barazzuol - Cancers, 2021 - mdpi.com
Simple Summary Side effects caused by the concomitant irradiation of normal tissue during
radiotherapy for cancer treatment can negatively affect the patient's quality of life and limit …

Spatial dose patterns associated with radiation pneumonitis in a randomized trial comparing intensity-modulated photon therapy with passive scattering proton …

G Palma, S Monti, T Xu, E Scifoni, P Yang… - International Journal of …, 2019 - Elsevier
Purpose Radiation pneumonitis (RP) is commonly associated with thoracic radiation
therapy, and its incidence is related to dose and volume of the normal lung in the path of …

[HTML][HTML] Radiation pneumonitis in thoracic cancer patients: Multi-center voxel-based analysis

G Palma, S Monti, R Pacelli, Z Liao, JO Deasy… - Cancers, 2021 - mdpi.com
Simple Summary The pathophysiology of radiation pneumonitis (RP) after thoracic cancer
radiation treatments is still not completely understood although the identification of …

[HTML][HTML] PACE: a probabilistic atlas for normal tissue complication estimation in radiation oncology

G Palma, S Monti, A Buonanno, R Pacelli… - Frontiers in …, 2019 - frontiersin.org
In radiation oncology, the need for a modern Normal Tissue Complication Probability
(NTCP) philosophy to include voxel-based evidence on organ radio-sensitivity (RS) has …

Spatial signature of dose patterns associated with acute radiation-induced lung damage in lung cancer patients treated with stereotactic body radiation therapy

G Palma, S Monti, M Thor, A Rimner… - Physics in Medicine …, 2019 - iopscience.iop.org
Thoracic radiation therapy (RT) is often associated with lung side effects, whose etiology is
still controversial. Our aim was to explore correlations between local dose in the thoracic …

Voxel-by-voxel correlation between radiologically radiation induced lung injury and dose after image-guided, intensity modulated radiotherapy for lung tumors

M Avanzo, S Barbiero, M Trovo, JP Bissonnette, R Jena… - Physica Medica, 2017 - Elsevier
Purpose To correlate radiation dose to the risk of severe radiologically-evident radiation-
induced lung injury (RRLI) using voxel-by-voxel analysis of the follow-up computed …

Radiation-induced lung injury—what do we know in the era of modern radiotherapy?

M Konkol, P Śniatała, P Milecki - reports of Practical …, 2022 - journals.viamedica.pl
Radiation-induced lung injury (RILI) that is usually divided into an early radiation-induced
pneumonitis (RIP) and late chronic radiation-induced lung fibrosis (RILF) remains a clinically …

Radiation-induced lung density changes on CT scan for NSCLC: no impact of dose-escalation level or volume

G Defraene, M La Fontaine, S van Kranen… - International Journal of …, 2018 - Elsevier
Purpose Dose-escalation for patients with non-small cell lung cancer (NSCLC) in the
positron emission tomography (PET)-boost trial (NCT01024829) exposes portions of normal …