Healthy human lungs have traditionally been considered to be a sterile organ. However,
culture-independent molecular techniques have reported that large numbers of microbes …

Bronchiectasis is characterised by pathological dilation of the airways. More specifically, the
radiographic demonstration of airway enlargement is the common feature of a …

Bronchiectasis, a progressive chronic airway disease, is characterized by microbial
colonization and infection. We present an approach to the multi-biome that integrates …

Rationale: Recent studies have revealed that, in critically ill patients, lung microbiota are
altered and correlate with alveolar inflammation. The clinical significance of altered lung …

Rationale: Bronchiectasis is classically considered a neutrophilic disorder, but eosinophilic
subtypes have recently been described. Objectives: To use multiple datasets available …

The lungs were long thought to be sterile until technical advances uncovered the presence
of the lung microbial community. The microbiome of healthy lungs is mainly derived from the …

The lungs are not sterile or free from bacteria; rather, they harbor a distinct microbiome
whose composition is driven by different ecological rules than for the gastrointestinal tract …

Although the notion that “the normal lung is free from bacteria” remains common in
textbooks, it is virtually always stated without citation or argument. The lungs are constantly …

Background Chronic infection and concomitant airway inflammation is the leading cause of
morbidity and mortality for people living with cystic fibrosis (CF). Although chronic infection in …

The principles of respiratory microbiology are being re-evaluated and re-written, starting with
the debunked myth of lung sterility. The “terrain” of the respiratory ecosystem differs …